The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Childhood obesity is one of the most serious global public-health challenges of the twenty-
first century. Over the past four decades, the number of children and adolescents with …

Diabetes mellitus (DM) is a chronic metabolic disease which causes millions of death all
over the world each year, and its incidence is on increase. The most prevalent form, type 2 …

The membrane-associated RING-CH (MARCH) proteins are E3 ligases that regulate the
stability of various cellular membrane proteins. MARCH8 has been reported to inhibit the …

The insulin receptor (IR) is a type II receptor tyrosine kinase that plays essential roles in
metabolism, growth, and proliferation. Dysregulation of IR signaling is linked to many human …

The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when
overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the …

Astronauts experience dramatic loss of muscle mass, decreased strength, and insulin
resistance, despite performing daily intense physical exercise that would lead to muscle …

The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases
have emerged as critical regulators of immune responses. MARCH proteins target immune …

Preferably, lifespan-extending therapies should work when applied late in life without
causing undesired pathologies. Reducing insulin/insulin-like growth factor (IGF)-1 signaling …