Several studies proposed the importance of zinc ion in male fertility. Here, we describe the
properties, roles and cellular mechanisms of action of Zn2+ in spermatozoa, focusing on its …

This review adds the bilin-binding phytochromes to the Chemical Reviews thematic issue
“Optogenetics and Photopharmacology”. The work is structured into two parts. We first …

The primary cilium projects from the surface of most vertebrate cells, where it senses
extracellular signals to regulate diverse cellular processes during tissue development and …

Primary cilia project from the surface of most vertebrate cells and are key in sensing
extracellular signals and locally transducing this information into a cellular response. Recent …

Abstract The 3′, 5′-cyclic adenosine monophosphate (cAMP) dependent protein kinase
(PKA) is a tetrameric holoenzyme comprising a set of two regulatory subunits (PKA-R) and …

Soluble adenylyl cyclase (sAC: ADCY10) has been genetically confirmed to be essential for
male fertility in mice and humans. In mice, ex vivo studies of dormant, caudal epididymal …

Background Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger
that transduces extracellular signals in virtually all eukaryotic cells. The soluble Beggiatoa …

Sperm chemotaxis, which guide sperm toward oocyte, is tightly associated with sperm
capacitation, motility, and fertility. However, the molecular mechanism of sperm chemotaxis …

Cilia, which either generate coordinated motion or sense environmental cues and transmit
corresponding signals to the cell body, are highly conserved hair-like structures that …

Sperm hyperactivation is described as a fast whip movement of the flagellum, an irregular
trajectory, and an asymmetrically flagellum bend. This motility pattern is achieved during the …