Transition metal–catalyzed cross-coupling reactions are some of the most widely used
methods in chemical synthesis. However, despite notable advantages of iron (Fe) as a …

Difluorocarbene has important applications in pharmaceuticals, agrochemicals and
materials, but all these applications proceed using just a few types of reaction by taking …

The selective difluoromethylene insertion into a C–Cu bond is a challenging task and is
currently limited to either a single CF2 insertion into CuCF3 or double CF2 insertions into …

We have developed a new strategy for controllable single and double difluoromethylene
(CF2) formal insertions into C− H bonds of aldehydes with nearly full selectivity under …

Optimization of compound lipophilicity is a key aspect of drug discovery. The aim of this work
was to compare the lipophilicity modulations induced by 16 distinct known and novel …

The mechanism of CF2 transfer from TMSCF3 (1), mediated by TBAT (2–12 mol%) or by NaI
(5–20 mol%), has been investigated by in situ/stopped-flow 19F NMR spectroscopic …

Alkene hydrodifluoroalkylation is a fruitful strategy for synthesizing difluoromethylated
compounds that are interesting for developing new medicinal agents, agrochemicals, and …

Organic molecules with fluoroalkylene scaffolds, especially a tetrafluoroethylene (CF2CF2)
moiety, in their molecular structures exhibit unique biological activities, or can be applied to …

The ability of sodium hypophosphite to generate the phosphorus-centered radical, which
can activate the carbon–halogen bond via the halogen atom transfer (XAT) is described. The …

A new fluorinated azidoethane─ 1-azido-1, 1, 2, 2-tetrafluoroethane─ was prepared in
quantitative yield by the addition of an azide anion to tetrafluoroethylene in a protic medium …