Background: Crigler-Najjar syndrome (CNS, OMIM: 218800) is the paradigm of an inborn
error of metabolism and a rare genetic disease with an estimated incidence of 0.6–1.0 per …

Pharmacogenomics is a tool for practitioners to provide precision pharmacotherapy using
genomics. All providers are likely to encounter genomic data in practice with the expectation …

Background Warfarin is the most widely used oral anticoagulant worldwide, but it has a
narrow therapeutic index which necessitates constant monitoring of anticoagulation …

The ideal dose of the oral anticoagulant warfarin varies widely among patients, mainly due
to genetic factors. Genetic variations that impact warfarin pharmacokinetics and the vitamin …

Warfarin exhibits a wide variation in dose requirements. We sought to evaluate the
association of polymorphisms CYP2C9* 2 (rs1799853), CYP2C9* 3 (rs1075910), and …

Purpose The aim of this study was to investigate the contributions of non-genetic and
genetic factors on the variability of stable warfarin doses in Thai patients. Methods A total of …

We searched PubMed entries and the Lattes database of Brazilian Pharmacogenetics
Network investigators, for pharmacogenetic/genomic (PGx) studies in the Brazilian …

Background: Polymorphisms in the CYP2C9, VKORC1, MDR1 and APOE genes may impact
warfarin dose. Aim: To investigate the influence of sociodemographic, clinical factors and …

The aim of this work was to review several studies investigating the effects of genetic
polymorphisms on warfarin dosing in regional and Iraqi studies and to report any consistent …

Purpose This study was designed to evaluate the association of non-genetic factors and
polymorphisms CYP2C9* 2 (rs1799853), CYP2C9* 3 (rs1075910), and VKORC1-G1639A …