Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and
BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for …

Background To systematically assess the prevalence of BRCA1 and BRCA2 gene mutations
in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to …

Doxorubicin (DOX), a prominent anticancer agent has enjoyed considerable popularity in
the last few decades because of its usefulness in the management of various forms of …

Background Elucidation of specific and recurrent/founder pathogenic variants (PVs) in
BRCA (BRCA1 and BRCA2) genes can make the genetic testing, for breast cancer (BC) …

Purpose. Breast cancer is the most common malignancy among women in Lebanon and in
Arab countries, with 50% of cases presenting before the age of 50 years. Methods. Between …

Background Deleterious germline mutations in BRCA1 and BRCA2 genes are associated
with a high risk of breast and ovarian cancer. In many developing countries, including Egypt …

Ovarian cancer (OC) is a common disease among Arabs, with one of the highest incidences
in the world. OC is underdiagnosed, underreported, and mostly reported with breast cancer …

Background Breast cancer is the most common malignancy and the leading cause of cancer-
related deaths among Jordanian women. With a median age of 50 years at diagnosis, a …

BRCA1 gene mutations account for about 25-28% of hereditary Breast Cancer as BRCA1 is
included in the category of high penetrance genes. Except for few commonmutations, there …

The 185delAG* BRCA1 mutation is encountered primarily in Jewish Ashkenazi and Iraqi
individuals, and sporadically in non-Jews. Previous studies estimated that this is a founder …