Twenty years of evolution of CML therapy: how the treatment goal is moving from disease to patient
D Russo, M Malagola, N Polverelli… - Therapeutic …, 2023 - journals.sagepub.com
The introduction of imatinib in 2000 opened the era of tyrosine kinase inhibitors (TKIs) for
CML therapy and has revolutionized the life expectancy of CML patients, which is now quite …
CML therapy and has revolutionized the life expectancy of CML patients, which is now quite …
[HTML][HTML] MicroRNA‑93 knockdown inhibits acute myeloid leukemia cell growth via inactivating the PI3K/AKT pathway by upregulating DAB2
J Huang, R Xiao, X Wang… - International …, 2021 - spandidos-publications.com
Acute myeloid leukemia (AML) is associated with a poor prognosis in elderly adults and
currently lacks optimal treatment strategies. MicroRNAs (miRNAs or miRs) have increasingly …
currently lacks optimal treatment strategies. MicroRNAs (miRNAs or miRs) have increasingly …
[HTML][HTML] Identifying the personalized driver gene sets maximally contributing to abnormality of transcriptome phenotype in glioblastoma multiforme individuals
J Xu, B Pang, Y Lan, R Dou, S Wang, S Kang… - Molecular …, 2023 - ncbi.nlm.nih.gov
High heterogeneity in genome and phenotype of cancer populations made it difficult to apply
population‐based common driver genes to the diagnosis and treatment of cancer …
population‐based common driver genes to the diagnosis and treatment of cancer …
[HTML][HTML] Development of BCR-ABL1 transgenic zebrafish model reproducing chronic myeloid leukemia (CML) like-disease and providing a new insight into CML …
Zebrafish has proven to be a versatile and reliable experimental in vivo tool to study human
hematopoiesis and model hematological malignancies. Transgenic technologies enable the …
hematopoiesis and model hematological malignancies. Transgenic technologies enable the …
[HTML][HTML] Validation of a Drosophila model of wild-type and T315I mutated BCR-ABL1 in chronic myeloid leukemia: an effective platform for treatment screening
A Al Outa, D Abubaker, A Bazarbachi… - …, 2019 - pmc.ncbi.nlm.nih.gov
Chronic myeloid leukemia (CML) is caused by a balanced chromosomal translocation
resulting in the formation of BCR-ABL1 fusion gene encoding a constitutively active BCR …
resulting in the formation of BCR-ABL1 fusion gene encoding a constitutively active BCR …
[HTML][HTML] Expression of chronic myeloid leukemia oncogenes BCR-ABL P210 and BCR-ABL T315I affect cellular and humoral innate immunity in Drosophila …
D Abubaker, A Baassiri, M Ghannam… - Micropublication …, 2022 - ncbi.nlm.nih.gov
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that results from a
chromosomal translocation between chromosome 9 and chromosome 22. The resulting …
chromosomal translocation between chromosome 9 and chromosome 22. The resulting …
[HTML][HTML] The leukemic fly: Promises and challenges
Leukemia involves different types of blood cancers, which lead to significant mortality and
morbidity. Murine models of leukemia have been instrumental in understanding the biology …
morbidity. Murine models of leukemia have been instrumental in understanding the biology …
[HTML][HTML] Genetic screening for potential new targets in chronic myeloid leukemia based on drosophila transgenic for human BCR-ABL1
M Lo Iacono, E Signorino, J Petiti, M Pradotto… - Cancers, 2021 - mdpi.com
Simple Summary Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm
characterized by the presence of the Philadelphia chromosome that encodes for the tyrosine …
characterized by the presence of the Philadelphia chromosome that encodes for the tyrosine …
TGFΒ 2 RS79375991 GENE POLYMORPHISM IN IRAQI CHRONIC MYELOID LEUKEMIA PATIENTS INFECTIOUS WITH HUMAN HERPES VIRUS-8
NE Issa, SHMA Alwany - Obstetrics and …, 2024 - obstetricsandgynaecologyforum.com
Background: HHV8+ primary effusion lymphoma (PEL), EB-LBCL has no known association
with HIV or HHV8 infection. Plural or pericardial effusions complicate BCR:: ABL1-positive …
with HIV or HHV8 infection. Plural or pericardial effusions complicate BCR:: ABL1-positive …
[PDF][PDF] USE OF Drosophila melanogaster AS A MODEL TO STUDY CHRONIC MYELOID LEUKEMIA
E Signorino - 2020 - iris.unito.it
USE OF Drosophila melanogaster AS A MODEL TO STUDY CHRONIC MYELOID LEUKEMIA Page
1 1 UNIVERSITY OF TURIN DEPARTMENT OF CLINICAL AND BIOLOGICAL SCIENCES PhD …
1 1 UNIVERSITY OF TURIN DEPARTMENT OF CLINICAL AND BIOLOGICAL SCIENCES PhD …