Highlights•In silico models facilitate the expert to evaluate toxicity, analyzing results of a
battery of models.•In silico models can address among others, the presence of structural …

Investigative toxicology describes the de-risking and mechanistic elucidation of toxicities,
supporting early safety decisions in the pharmaceutical industry. Recently, investigative …

In the last years, attention has been devoted to the development of ontologies, which are ICT
conceptual models allowing a formal and shared representation of a particular domain of …

Despite wide-spread consensus on the need to transform toxicology and risk assessment in
order to keep pace with technological and computational changes that have revolutionized …

A good experiment reported badly is worthless. Meaningful contributions to the body of
science are made by sharing the full methodology and results so that they can be evaluated …

A biological system is more than the sum of its parts–it accomplishes many functions via
synergy. Deconstructing the system down to the molecular mechanism level necessitates …

When performing safety assessment of chemicals, the evaluation of their systemic toxicity
based only on non-animal approaches is a challenging objective. The Safety Evaluation …

Summary The Human Toxome Project, funded as an NIH Transformative Research grant
2011–2016, is focused on developing the concepts and the means for deducing, validating …

Systematic evidence mapping offers a robust and transparent methodology for facilitating
evidence-based approaches to decision-making in chemicals policy and wider …

Traditional results from toxicogenomics studies are complex lists of significantly impacted
genes or gene sets, which are challenging to synthesize down to actionable results with a …