Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in
tumour progression from malignant transformation to metastasis and immune evasion. One …

Glycosylation changes are key molecular events in tumorigenesis, progression and
glycosyltransferases play a vital role in the this process. FUT8 belongs to the …

FUT8 is an essential α-1, 6-fucosyltransferase that fucosylates the innermost GlcNAc of N-
glycans, a process called core fucosylation. In vitro, FUT8 exhibits substrate preference for …

Highlights•Aberrant fucosylation is a signature of malignant cell transformation and
modulates the occurrence and development of cancer.•Targeting fucosyltransferases (FUTs) …

N-glycosylation is a highly conserved glycan modification, and more than 7000 proteins are
N-glycosylated in humans. N-glycosylation has many biological functions such as protein …

It is well known that numerous cancer-related changes occur in glycans that are attached to
glycoproteins, glycolipids and proteoglycans on the cell surface and these changes in …

Mammalian cell surfaces are modified with complex arrays of glycans that play major roles
in health and disease. Abnormal glycosylation is a hallmark of cancer; terminal sialic acid …

Mammalian Asn-linked glycans are extensively processed as they transit the secretory
pathway to generate diverse glycans on cell surface and secreted glycoproteins. Additional …

Glycosyltransferases are a large family of enzymes responsible for covalently linking sugar
monosaccharides to a variety of organic substrates. These enzymes drive the synthesis of …

Core fucosylation is catalyzed by α‐1, 6‐fucosyltransferase (FUT8), which fucosylates the
innermost GlcNAc of N‐glycans. Given the association of FUT8 with various diseases …