Lipid rafts: controversies resolved, mysteries remain

I Levental, KR Levental, FA Heberle - Trends in cell biology, 2020 - cell.com
The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …

Periodontitis: from microbial immune subversion to systemic inflammation

G Hajishengallis - Nature reviews immunology, 2015 - nature.com
Periodontitis is a dysbiotic inflammatory disease with an adverse impact on systemic health.
Recent studies have provided insights into the emergence and persistence of dysbiotic oral …

Cholesterol-rich lipid rafts as platforms for SARS-CoV-2 entry

SN Palacios-Rápalo, LA De Jesus-Gonzalez… - Frontiers in …, 2021 - frontiersin.org
Since its appearance, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2),
the causal agent of Coronavirus Disease 2019 (COVID-19), represents a global problem for …

The role of cholesterol in membrane fusion

ST Yang, AJB Kreutzberger, J Lee, V Kiessling… - Chemistry and physics …, 2016 - Elsevier
Cholesterol modulates the bilayer structure of biological membranes in multiple ways. It
changes the fluidity, thickness, compressibility, water penetration and intrinsic curvature of …

SARS coronavirus entry into host cells through a novel clathrin-and caveolae-independent endocytic pathway

H Wang, P Yang, K Liu, F Guo, Y Zhang, G Zhang… - Cell research, 2008 - nature.com
While severe acute respiratory syndrome coronavirus (SARS-CoV) was initially thought to
enter cells through direct fusion with the plasma membrane, more recent evidence suggests …

The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry

S Amini-Bavil-Olyaee, YJ Choi, JH Lee, M Shi… - Cell host & …, 2013 - cell.com
Vesicle-membrane-protein-associated protein A (VAPA) and oxysterol-binding protein
(OSBP) regulate intracellular cholesterol homeostasis, which is required for many virus …

Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion

GN Schroeder, H Hilbi - Clinical microbiology reviews, 2008 - Am Soc Microbiol
Shigella spp. are gram-negative pathogenic bacteria that evolved from harmless
enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research …

SARS-CoV-2 evolutionary adaptation toward host entry and recognition of receptor O-Acetyl sialylation in virus–host interaction

CH Kim - International journal of molecular sciences, 2020 - mdpi.com
The recently emerged SARS-CoV-2 is the cause of the global health crisis of the coronavirus
disease 2019 (COVID-19) pandemic. No evidence is yet available for CoV infection into …

Greasing their way: lipid modifications determine protein association with membrane rafts

I Levental, M Grzybek, K Simons - Biochemistry, 2010 - ACS Publications
Increasing evidence suggests that biological membranes can be laterally subdivided into
domains enriched in specific lipid and protein components and that these domains may be …

Mass spectrometry techniques in emerging pathogens studies: COVID-19 perspectives

I Mahmud, TJ Garrett - Journal of the American Society for Mass …, 2020 - ACS Publications
As corona virus disease 2019 (COVID-19) is a rapidly growing public health crisis across the
world, our knowledge of meaningful diagnostic tests and treatment for severe acute …