Abstract α-Synuclein is an abundant neuronal protein which localizes predominantly to
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …

Parkinson's disease is a progressive neurological disorder that is characterized by the
formation of intracellular protein inclusion bodies composed primarily of a misfolded and …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Genetic and pathological studies link α-synuclein to the etiology of Parkinson's disease
(PD), but the normal function of this presynaptic protein remains unknown. α-Synuclein, an …

Misfolded α-synuclein is a key factor in the pathogenesis of Parkinson's disease (PD).
However, knowledge about a physiological role for the native, unfolded α-synuclein is …

Neurotransmission relies critically on the exocytotic release of neurotransmitters from small
synaptic vesicles (SVs) at the active zone. Therefore, it is essential for neurons to maintain …

Summary α-synuclein, β-synuclein, and γ-synuclein are abundantly expressed proteins in
the vertebrate nervous system. α-synuclein functions in neurotransmitter release by binding …

α-, β-, and γ-Synuclein are intrinsically disordered proteins implicated in physiological
processes in the nervous system of vertebrates. α-synuclein (αSyn) is the amyloidogenic …

Synuclein family consists of three members, α, β, and γ-synuclein. Due to their involvement
in human diseases, they have been thoroughly investigated for the last 30 years. Since the …

Alpha-synuclein is a predominant player in the pathogenesis of Parkinson's Disease.
However, despite extensive study for two decades, its physiological and pathological …