Pharmacological treatment of acquired QT prolongation and torsades de pointes

SHL Thomas, ER Behr - British journal of clinical pharmacology, 2016 - Wiley Online Library
Torsades de pointes (TdP) is a characteristic polymorphic ventricular arrhythmia associated
with delayed ventricular repolarization as evidenced on the surface electrocardiogram by QT …

Neuromodulation for ventricular tachycardia and atrial fibrillation: a clinical scenario-based review

C Zhu, P Hanna, PS Rajendran, K Shivkumar - JACC: Clinical …, 2019 - jacc.org
Autonomic dysregulation in cardiovascular disease plays a major role in the pathogenesis of
arrhythmias. Cardiac neural control relies on complex feedback loops consisting of efferent …

Safe electrophysiologic profile of dexmedetomidine in different experimental arrhythmia models

C Ellermann, J Brandt, J Wolfes, K Willy, FK Wegner… - Scientific reports, 2021 - nature.com
Previous studies suggest an impact of dexmedetomidine on cardiac electrophysiology.
However, experimental data is sparse. Therefore, purpose of this study was to investigate …

Effects of dexmedetomidine on cardiac electrophysiology in patients undergoing general anesthesia during perioperative period: a randomized controlled trial

C Tan, S Yan, J Shen, H Wu, L Yu, Y Wang, S Tian… - BMC …, 2022 - Springer
Background Dexmedetomidine has controversial influence on cardiac electrophysiology.
The aim of this study was to explore the effects of dexmedetomidine on perioperative cardiac …

Effects of dexmedetomidine on basic cardiac electrophysiology in adults; a descriptive review and a prospective case study

R Pöyhiä, T Nieminen, VWT Tuompo, H Parikka - Pharmaceuticals, 2022 - mdpi.com
Dexmedetomidine (DEX) is a commonly used sedative agent with no or minimal effects on
breathing. DEX may also be beneficial in myocardial protection. Since the mechanisms of …

Transgenic rabbit models to investigate the cardiac ion channel disease long QT syndrome

CN Lang, G Koren, KE Odening - Progress in Biophysics and Molecular …, 2016 - Elsevier
Long QT syndrome (LQTS) is a rare inherited channelopathy caused mainly by different
mutations in genes encoding for cardiac K+ or Na+ channels, but can also be caused by …

Effects of dexmedetomidine on changes in heart rate variability and hemodynamics during tracheal intubation

JS Cho, SH Kim, S Shin, HN Pak… - American Journal of …, 2016 - journals.lww.com
Sympathetic hyperactivation during tracheal intubation prolongs the QT interval and
increases the risk of arrhythmias. We investigated if dexmedetomidine pretreatment affected …

Dexmedetomidine exerted anti-arrhythmic effects in rat with ischemic cardiomyopathy via upregulation of connexin 43 and reduction of fibrosis and inflammation

S Wu, Z Lin, Y Lin, Z Rao, J Lin, L Wu, L Li - Frontiers in Physiology, 2020 - frontiersin.org
Background Persistent myocardial ischemia post-myocardial infarction can lead to fatal
ventricular arrhythmias such as ventricular tachycardia and fibrillation, both of which carry …

[HTML][HTML] Modulation of the QT interval duration in hypertension with antihypertensive treatment

J Klimas, P Kruzliak, SW Rabkin - Hypertension Research, 2015 - nature.com
The duration of the QT interval as measured by 12-lead electrocardiography is a measure of
myocardial repolarization and is widely used to describe cardiac abnormalities, to determine …

Heart rate variability dynamics during controlled hypotension with nicardipine, remifentanil and dexmedetomidine

S Shin, JW Lee, SH Kim, YS JUNG… - Acta Anaesthesiologica …, 2014 - Wiley Online Library
Background This study was done to investigate how nicardipine, remifentanil and
dexmedetomidine affect the balance of the autonomic nervous system in patients receiving …