Cutaneous leishmaniasis: immune responses in protection and pathogenesis

P Scott, FO Novais - Nature Reviews Immunology, 2016 - nature.com
Cutaneous leishmaniasis is a major public health problem and causes a range of diseases
from self-healing infections to chronic disfiguring disease. Currently, there is no vaccine for …

Leishmaniasis in humans: drug or vaccine therapy?

M Ghorbani, R Farhoudi - Drug design, development and therapy, 2017 - Taylor & Francis
Leishmania is an obligate intracellular pathogen that invades phagocytic host cells.
Approximately 30 different species of Phlebotomine sand flies can transmit this parasite …

Emerging and reemerging neglected tropical diseases: a review of key characteristics, risk factors, and the policy and innovation environment

TK Mackey, BA Liang, R Cuomo, R Hafen… - Clinical microbiology …, 2014 - Am Soc Microbiol
In global health, critical challenges have arisen from infectious diseases, including the
emergence and reemergence of old and new infectious diseases. Emergence and …

Possibilities and challenges for developing a successful vaccine for leishmaniasis

S Srivastava, P Shankar, J Mishra, S Singh - Parasites & vectors, 2016 - Springer
Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …

Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection

ND Glennie, VA Yeramilli, DP Beiting… - Journal of Experimental …, 2015 - rupress.org
Leishmaniasis causes a significant disease burden worldwide. Although Leishmania-
infected patients become refractory to reinfection after disease resolution, effective immune …

From infection to vaccination: reviewing the global burden, history of vaccine development, and recurring challenges in global leishmaniasis protection

G Volpedo, RH Huston, EA Holcomb… - Expert review of …, 2021 - Taylor & Francis
Introduction Leishmaniasis is a major public health problem and the second most lethal
parasitic disease in the world due to the lack of effective treatments and vaccines. Even …

Leishmaniasis vaccine: where are we today?

L Kedzierski - Journal of global infectious diseases, 2010 - journals.lww.com
Leishmaniasis is a disease that ranges in severity from skin lesions to serious disfigurement
and fatal systemic infection. WHO has classified the disease as emerging and uncontrolled …

Neglected and endemic zoonoses

I Maudlin, MC Eisler… - … Transactions of the …, 2009 - royalsocietypublishing.org
Endemic zoonoses are found throughout the developing world, wherever people live in
close proximity to their animals, affecting not only the health of poor people but often also …

Vaccine candidates for leishmaniasis: a review

R Nagill, S Kaur - International immunopharmacology, 2011 - Elsevier
Leishmaniasis is a diverse group of clinical syndromes caused by protozoan parasites of the
genus Leishmania. The clinical manifestation of the disease varies from self-limiting …

Immunological perspectives of leishmaniasis

S Nylén, S Gautam - Journal of global infectious diseases, 2010 - journals.lww.com
Leishmania parasites have been widely used in experimental models to understand
generation, maintenance and failure of immune responses underlying resistance and …