All nervous systems are subject to neuromodulation. Neuromodulators can be delivered as
local hormones, as cotransmitters in projection neurons, and through the general circulation …

Neurons in most animals live a very long time relative to the half-lives of all of the proteins
that govern excitability and synaptic transmission. Consequently, homeostatic mechanisms …

Mechanistic modeling in neuroscience aims to explain observed phenomena in terms of
underlying causes. However, determining which model parameters agree with complex and …

Mechanistic models of single-neuron dynamics have been extensively studied in
computational neuroscience. However, identifying which models can quantitatively …

We introduce a two-dimensional integrate-and-fire model that combines an exponential
spike mechanism with an adaptation equation, based on recent theoretical findings. We …

Simulation-based inference (SBI) solves statistical inverse problems by repeatedly running a
stochastic simulator and inferring posterior distributions from model-simulations. To improve …

It is often assumed that cellular and synaptic properties need to be regulated to specific
values to allow a neuronal network to function properly. To determine how tightly neuronal …

There is a high diversity of neuronal types in the mammalian neocortex. To facilitate
construction of system models with multiple cell types, we generate a database of point …

Highlights•Modulation of synaptic strength can occur through changes in short-term
plasticity.•Modulators can shape or induce long-term synaptic plasticity.•Modulators can …

How tightly tuned are the synaptic and intrinsic properties that give rise to neuron and circuit
function? Experimental work shows that these properties vary considerably across identified …