One immune cell to bind them all: platelet contribution to neurodegenerative disease
G Rodriguez Moore, I Melo-Escobar, D Stegner… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) and related dementias (ADRD) collectively affect a significant
portion of the aging population worldwide. The pathological progression of AD involves not …
portion of the aging population worldwide. The pathological progression of AD involves not …
Ischemia/reperfusion injury in acute human and experimental stroke: focus on thrombo-inflammatory mechanisms and treatments
G Stoll, B Nieswandt, MK Schuhmann - Neurological Research and …, 2024 - Springer
Background Despite high recanalization rates of> 90% after endovascular thrombectomy
(EVT) clinical outcome in around 50% of treated acute ischemic stroke (AIS) patients is still …
(EVT) clinical outcome in around 50% of treated acute ischemic stroke (AIS) patients is still …
Thromboinflammation is associated with clinical outcome after ST-elevation myocardial infarction
M Benkhoff, K Alde, V Ehreiser, J Dahlmanns… - Blood …, 2024 - ashpublications.org
Platelets are crucial in thrombus formation during ST-elevation myocardial infarction
(STEMI). In addition, they also play an important role in postischemic thromboinflammation …
(STEMI). In addition, they also play an important role in postischemic thromboinflammation …
The quest for the holy grail in antithrombotic therapy: revitalized hope for platelet GPVI as a safe and effective antithrombotic target
Collagen binds to the platelet GPVI receptor and triggers platelet activation via the Fc
receptor γ (FcRγ) chain which contains an immunoreceptor tyrosine-based activation motif …
receptor γ (FcRγ) chain which contains an immunoreceptor tyrosine-based activation motif …
Ischaemic heart disease: Focus on sex-related differences and novel therapeutic targets
F Crea - European Heart Journal, 2024 - academic.oup.com
University of Zurich in Switzerland, and colleagues. 1 The authors point out that cardiogenic
shock (CS) remains the primary cause of inhospital death after acute coronary syndromes …
shock (CS) remains the primary cause of inhospital death after acute coronary syndromes …
Comparative Effects of Glenzocimab and Eptifibatide on Bleeding Severity in 2 Mouse Models of Intracranial Hemorrhage
S Dupont, H Lebas, S Mavouna, E Pascal… - Journal of the …, 2025 - ahajournals.org
Background Antiplatelet drugs represent potential candidates for protecting the penumbral
microcirculation during cerebral ischemia and improving the benefits of arterial …
microcirculation during cerebral ischemia and improving the benefits of arterial …
A New Perspective on Mechanisms of Neurodegeneration in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis: the Early and Critical Role of …
JM Orian - Journal of Neuroimmune Pharmacology, 2025 - Springer
Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disorder, with limited
treatment options. This disease is characterized by differential pathophysiology between …
treatment options. This disease is characterized by differential pathophysiology between …
[HTML][HTML] Specificities of Myocardial Infarction and Heart Failure in Women
M Dekleva, A Djordjevic, S Zivkovic… - Journal of Clinical …, 2024 - mdpi.com
Substantial evidence from previous clinical studies, randomized trials, and patient registries
confirms the existence of significant differences in cardiac morphology, pathophysiology …
confirms the existence of significant differences in cardiac morphology, pathophysiology …
Is all collagen the same for platelet testing? Editorial on “platelet collagen receptors and their role in modulating platelet adhesion patterns and activation on …
K Mott - Thrombosis Research, 2025 - thrombosisresearch.com
Collagens are the most abundant proteins in vertebrates and make up 90% of all
extracellular matrix proteins [1, 2]. As essential structural components of the subendothelial …
extracellular matrix proteins [1, 2]. As essential structural components of the subendothelial …