Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Developmental programs that generate the astonishing neuronal diversity of the nervous
system are not completely understood and thus present a major challenge for clinical …

Astrocytes play essential roles in development, homeostasis, injury, and repair of the central
nervous system (CNS). Their development is tightly regulated by distinct spatial and …

Temporal lobe epilepsy (TLE) is a common drug-resistant epilepsy associated with
abundant cell death in the hippocampus. Here, we develop a novel gene therapy-mediated …

Direct neuronal reprogramming is an innovative new technology that involves the
conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent …

Within just over a decade, human reprogramming‐based disease modeling has developed
from a rather outlandish idea into an essential part of disease research. While iPSCs are a …

Astrocytes are a viable source for generating new neurons via direct conversion. However,
little is known about the neurogenic cascades triggered in astrocytes from different regions …

The on-target pioneer factors Ascl1 and Myod1 are sequence-related but induce two
developmentally unrelated lineages—that is, neuronal and muscle identities, respectively. It …

Cellular identity is established through complex layers of genetic regulation, forged over a
developmental lifetime. An expanding molecular toolbox is allowing us to manipulate these …