Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

Elevated intracellular Ca 2+ triggers inactivation of L-type calcium channels, providing
negative Ca 2+ feedback in many cells. Ca 2+ binding to the main α 1C channel subunit has …

L-type Ca2+ channels support Ca2+ entry into cells, which triggers cardiac contraction,
controls hormone secretion from endocrine cells and initiates transcriptional events that …

We have developed a mathematical model of the human atrial myocyte based on averaged
voltage-clamp data recorded from isolated single myocytes. Our model consists of a …

In spite of the recognition that striatal D2 receptors are critical determinants in a variety of
psychomotor disorders, the cellular mechanisms by which these receptors shape neuronal …

Ca2+ transients measured in failing human ventricular myocytes exhibit reduced amplitude,
slowed relaxation, and blunted frequency dependence. In the companion article (O'Rourke …

Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels
comprises a prominent prototype for ion channel regulation, remarkable for its powerful …

Mathematical modeling of the cardiac action potential has proven to be a powerful tool for
illuminating various aspects of cardiac function, including cardiac arrhythmias. However, no …

Astroglia possess excitability based on movements of Ca2+ ions between intracellular
compartments and plasmalemmal Ca2+ fluxes. This “Ca2+ excitability” is controlled by …