The immuno-oncological challenge of COVID-19

L Derosa, C Melenotte, F Griscelli, B Gachot… - Nature Cancer, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) and its causative virus, SARS-CoV-2, pose
considerable challenges for the management of oncology patients. COVID-19 presents as a …

The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV

N Hemmat, Z Asadzadeh, NK Ahangar… - Archives of …, 2021 - Springer
The number of descriptions of emerging viruses has grown at an unprecedented rate since
the beginning of the 21 st century. Severe acute respiratory syndrome coronavirus 2 (SARS …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

Low level of plasminogen increases risk for mortality in COVID-19 patients

D Della-Morte, F Pacifici, C Ricordi, R Massoud… - Cell death & …, 2021 - nature.com
The pathophysiology of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), and especially of its complications is still …

[HTML][HTML] Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection

F Ciccosanti, M Di Rienzo, A Romagnoli, F Colavita… - Antiviral research, 2021 - Elsevier
COVID-19 is currently a highly pressing health threat and therapeutic strategies to mitigate
the infection impact are urgently needed. Characterization of the SARS-CoV-2 interactome …

[PDF][PDF] Impact of computational approaches in the fight against COVID-19: an AI guided review of 17 000 studies

F Napolitano, X Xu, X Gao - Briefings in bioinformatics, 2022 - academic.oup.com
SARS-CoV-2 caused the first severe pandemic of the digital era. Computational approaches
have been ubiquitously used in an attempt to timely and effectively cope with the resulting …

Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19

GJS Pereira, AHFF Leao, AG Erustes… - International journal of …, 2021 - mdpi.com
The family of coronaviruses (CoVs) uses the autophagy machinery of host cells to promote
their growth and replication; thus, this process stands out as a potential target to combat …

Experimental models of SARS-CoV-2 infection: possible platforms to study COVID-19 pathogenesis and potential treatments

S Pandamooz, B Jurek, CP Meinung… - Annual review of …, 2022 - annualreviews.org
In December 2019, a novel coronavirus crossed species barriers to infect humans and was
effectively transmitted from person to person, leading to a worldwide pandemic …

[HTML][HTML] Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 …

M Milani, M Donalisio, RM Bonotto, E Schneider… - Antiviral research, 2021 - Elsevier
The current emergency of the novel coronavirus SARS-CoV2 urged the need for broad-
spectrum antiviral drugs as the first line of treatment. Coronaviruses are a large family of …

On the origins of SARS-CoV-2 main protease inhibitors

YL Janin - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
In order to address the world-wide health challenge caused by the COVID-19 pandemic, the
3CL protease/SARS-CoV-2 main protease (SARS-CoV-2-Mpro) coded by its nsp5 gene …