Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute
stress. They are best known as inducible transcriptional regulators of genes encoding …

The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …

SUMO (small ubiquitin-like modifier) modification regulates many cellular processes,
including transcription. Although sumoylation often occurs on specific lysines within the …

The development of mature blood cells of distinct lineages, from the hematopoietic stem
cells (HSCs), involves a progressive restriction of differentiation potential and the …

Transcriptional networks orchestrate complex developmental processes. Such networks are
commonly instigated by master regulators of development. Considerable progress has been …

The discovery of the GATA binding protein (GATA factor) transcription factor family
revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our …

Numerous examples exist of how disrupting the actions of physiological regulators of blood
cell development yields hematologic malignancies. The master regulator of hematopoietic …

GATA1 is considered as the “master” transcription factor in erythropoiesis. It regulates at the
transcriptional level all aspects of erythroid maturation and function, as revealed by gene …

The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory
regions of numerous genes. In vertebrates, these motifs are bound by one of six factors …

Human erythropoiesis is a complex multistep developmental process that begins at the level
of pluripotent hematopoietic stem cells (HSCs) at bone marrow microenvironment (HSCs …