Hyperpolarization is an emerging method in magnetic resonance imaging that allows
nuclear spin polarization of gases or liquids to be temporarily enhanced by up to five or six …

Over the last two decades, hyperpolarized 13 C MRI has gained significance in both
preclinical and clinical studies, hereby relying on technologies like PHIP-SAH …

Solid tumors such as prostate cancer (PCa) commonly develop an acidic microenvironment
with pH 6.5–7.2, owing to heterogeneous perfusion, high metabolic activity, and rapid cell …

We present a selectively pulsed (SP) generation of sequences to transfer the spin order of
parahydrogen (pH2) to heteronuclei in weakly coupled spin systems. We analyze and …

pH is a tightly regulated physiological parameter that is often altered in diseased states like
cancer. The development of biosensors that can be used to non-invasively image pH with …

In the search for powerful non‐invasive methods for pH measurement, NMR usually suffers
from biases, especially for heterogeneous samples or tissues. In this Communication, using …

Background Hyperpolarization enhances the sensitivity of nuclear magnetic resonance
experiments by between four and five orders of magnitude. Several hyperpolarized sensor …

Hyperpolarization is a method to enhance the nuclear magnetic resonance signal by up to
five orders of magnitude. However, the hyperpolarized (HP) state is transient and decays …

Magnetic resonance spectroscopy (MRS) allows the analysis of biochemical processes non-
invasively and in vivo. Still, its application in clinical diagnostics is rare. Routine MRS is …

Abstract pH alterations are a hallmark of many pathologies including cancer and kidney
disease. Here, we introduce [1, 5-13C2] Z-OMPD as a hyperpolarized extracellular pH and …