Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …

The cyclin-dependent kinase (CDK)–RB–E2F axis forms the core transcriptional machinery
driving cell cycle progression, dictating the timing and fidelity of genome replication and …

The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …

Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …

Abstract Background Long non-coding RNAs (lncRNAs) are crucial in the invasion,
angiogenesis, progression, and metastasis of hepatocellular carcinoma (HCC). The lncRNA …

During tumour development cells sustain mutations that disrupt normal mechanisms
controlling proliferation. Remarkably, the Rb–E2f and MDM2–p53 pathways are both …

Regulatory elements activate promoters by recruiting transcription factors (TFs) to specific
motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized …

Loss of RB1 gene is considered either a causal or an accelerating event in retinoblastoma.
A variety of mechanisms inactivates RB1 gene, including intragenic mutations, loss of …

The retinoblastoma tumor suppressor, pRb, restricts cell-cycle progression mainly by
regulating members of the E2F-transcription-factor family. The Rb pathway is often …

As major regulators of the cell cycle, apoptosis and differentiation, E2F transcription factors
have been studied extensively in a broad range of organisms. The recent identification of …