Genetically encoded biosensors are the vital components of synthetic biology and metabolic
engineering, as they are regarded as powerful devices for the dynamic control of genotype …

In nature, quorum sensing is one of the mechanisms bacterial populations use to
communicate with their own species or across species to coordinate behaviours. For the last …

Rapid advances in synthetic biology are driving the development of genetically engineered
microbes as therapeutic agents for a multitude of human diseases, including cancer. The …

Genetically programmed circuits allowing bifunctional dynamic regulation of enzyme
expression have far-reaching significances for various bio-manufactural purposes. However …

The l-arabinose-responsive AraC and its cognate PBAD promoter underlie one of the most
often used chemically inducible prokaryotic gene expression systems in microbiology and …

Microbes can convert inexpensive renewable substrates to valuable metabolites by their
natural metabolic pathways. To maximize the productivity, the pathways yet require further …

Highlights•Metabolic cybergenetics promises unprecedented real-time control of
fermentations.•Optogenetic regulators make ideal actuators for metabolic cybergenetics.• …

The remarkable metabolic diversity observed in nature has provided a foundation for
sustainable production of a wide array of valuable molecules. However, transferring the …

Antibiotics are a key control mechanism for synthetic biology and microbiology. Resistance
genes are used to select desired cells and regulate bacterial populations, however their use …

Dynamic control of microbial metabolism is an effective strategy to improve chemical
production in fermentations. While dynamic control is most often implemented using …