All living organisms require nutrient minerals for growth and have developed mechanisms to
acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment …

In recent years, the emergence of fungal resistance has become frequent, partly due to the
widespread clinical use of fluconazole, which is minimally toxic and effective in the …

Mitochondria-dependent programmed cell death (PCD) in yeast shares many features with
the intrinsic apoptotic pathway of mammals. With many stimuli, increased cytosolic [Ca 2+] …

Calcium ions are the most ubiquitous and versatile signaling molecules in eukaryotic cells.
Calcium homeostasis and signaling systems are crucial for both the normal growth of the …

Eukaryotic Ca2+ regulation involves sequestration into intracellular organelles, and
expeditious Ca2+ release into the cytosol is a hallmark of key signalling transduction …

The key players of calcium (Ca2+) homeostasis and Ca2+ signal generation, which are
Ca2+ channels, Ca2+/H+ antiporters, and Ca2+-ATPases, are present in all fungi. Their …

Calcium signaling depends on a tightly regulated set of pumps, exchangers and channels
that are responsible for controlling calcium fluxes between the different subcellular …

The origin of life on Earth is associated with the Precambrian era, in which the existence of a
large diversity of microbial fossils has been demonstrated. Notwithstanding, despite existing …

Proteolysis by aspartyl intramembrane proteases such as presenilin and signal peptide
peptidase (SPP) underlies many cellular processes in health and disease. Saccharomyces …

The ubiquitin–proteasome system (UPS) is the main proteolytic pathway by which damaged
target proteins are degraded after ubiquitination and the recruit of ubiquitinated proteins …