Damage to the adult CNS often leads to persistent deficits due to the inability of mature
axons to regenerate after injury. Mounting evidence suggests that the glial environment of …

Damage to the central nervous system (CNS) results in a glial reaction, leading eventually to
the formation of a glial scar. In this environment, axon regeneration fails, and remyelination …

Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic
functions. Despite extensive research in the last decades, SCI continues to be a global …

Repulsive guidance cues can steer neuronal growth cones during development and prevent
mature axons from regenerating. We have identified a 100 kd glycoprotein in the chick brain …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

Recent studies have expanded our knowledge, at the molecular level, of how myelin inhibits
axonal regeneration after injury to the mammalian central nervous system. Several inhibitors …

The membrane protein Nogo-A was initially characterized as a CNS-specific inhibitor of
axonal regeneration. Recent studies have uncovered regulatory roles of Nogo proteins and …

▪ Abstract The guidance of axons during the establishment of the nervous system is
mediated by a variety of extracellular cues that govern cytoskeletal dynamics in axonal …

Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes
and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and …

Nerve growth is regulated by attractive and repulsive factors in the nervous system.
Microscopic gradients of Collapsin-1/Semaphorin III/D (Sema III) and myelin-associated …