Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …

RNA-guided programmable nucleases from CRISPR systems generate precise breaks in
DNA or RNA at specified positions. In cells, this activity can lead to changes in DNA …

A major challenge in human genetics is to identify the molecular mechanisms of trait-
associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) …

Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion
and resistance to therapy. Here, using paired whole-exome and RNA sequencing data, we …

The COVID-19 outbreak has become a global health risk, and understanding the response
of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host …

Most patients with cancer either do not respond to immune checkpoint blockade or develop
resistance to it, often because of acquired mutations that impair antigen presentation. Here …

Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …

Current methods for programmed RNA editing using endogenous ADAR enzymes and
engineered ADAR-recruiting RNAs (arRNAs) suffer from low efficiency and bystander off …

Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Inosine is a prevalent RNA modification in animals and is formed when an adenosine is
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …