Mesenchymal stromal cell-conditioned medium for skin diseases: a systematic review

T Montero-Vilchez, Á Sierra-Sánchez… - Frontiers in cell and …, 2021 - frontiersin.org
The skin is the largest organ of the human body, and its dysfunction is related to many
diseases. There is a need to find new potential effective therapies for some skin conditions …

An update on the potential of mesenchymal stem cell therapy for cutaneous diseases

Y Li, Z Ye, W Yang, Q Zhang, J Zeng - Stem Cells International, 2021 - Wiley Online Library
Mesenchymal stem or stromal cells (MSCs) are nonhematopoietic postnatal stem cells with
self‐renewal, multipotent differentiation, and potent immunomodulatory and anti …

Identification and characterization of four immune-related signatures in keloid

X Wang, B Liang, J Li, X Pi, P Zhang, X Zhou… - Frontiers in …, 2022 - frontiersin.org
A keloid is a fibroproliferative disorder of unknown etiopathogenesis that requires ill-defined
treatment. Existing evidence indicates that the immune system plays an important role in the …

Circular RNA CircCOL5A1 sponges the MiR-7-5p/Epac1 axis to promote the progression of keloids through regulating PI3K/Akt signaling pathway

W Lv, S Liu, Q Zhang, W Hu, Y Wu… - Frontiers in Cell and …, 2021 - frontiersin.org
Keloids, as a result of abnormal wound healing in susceptible individuals, are characterized
by the hyper-proliferation of fibroblasts and exaggerated deposition of extracellular matrix …

Asporin inhibits collagen matrix‐mediated intercellular mechanocommunications between fibroblasts during keloid progression

L Liu, H Yu, Y Long, Z You, R Ogawa, Y Du… - The FASEB …, 2021 - Wiley Online Library
Keloids are fibrotic lesions that grow unceasingly and invasively and are driven by local
mechanical stimuli. Unlike other fibrotic diseases and normal wound healing, keloids exhibit …

Umbilical cord‐derived mesenchymal stem cell secretome promotes skin regeneration and rejuvenation: From mechanism to therapeutics

X Li, D Zhang, Y Yu, L Wang, M Zhao - Cell Proliferation, 2024 - Wiley Online Library
How to effectively repair cutaneous wounds and promote skin rejuvenation has always been
a challenging issue for clinical medicine and medical aesthetics. Current conventional …

IGFBP-7 secreted by adipose-derived stem cells inhibits keloid formation via the BRAF/MEK/ERK signaling pathway

F Liu, T Yu, J Liu, Q Yang, J Wu, J Ren, N Zhu - Journal of Dermatological …, 2023 - Elsevier
Background Adipose tissue-derived stem cells (ASCs) have important clinical significance
as regulators of skin scar tissue regeneration. ASCs inhibit keloid formation and increase …

Clinical evaluation of intralesional umbilical cord‐derived mesenchymal stem cells, conditioned medium and triamcinolone acetonide injection for keloid treatment: A …

AD Harsono, IH Dilogo, TOH Prasetyono… - International Wound …, 2024 - Wiley Online Library
Topical keloid therapy is performed with triamcinolone acetonide (TA) intralesional injection.
However, the recurrence rate is high with various side effects. Mesenchymal stem cells …

[HTML][HTML] Living cell for drug delivery

Y Wu, Y Liu, T Wang, Q Jiang, F Xu, Z Liu - Engineered Regeneration, 2022 - Elsevier
The living cells have been emerged as useful platforms for drug delivery due to their
advantages of good liquidity, stability, and low immunogenicity. In this review, we …

[HTML][HTML] Subcellular Fractionation and Metaproteogenomic Identification and Validation of Key Differentially Expressed Molecular Targets for Keloid Disease

EB Kidzeru, M Sinkala, T Chalwa, R Matobole… - Journal of Investigative …, 2024 - Elsevier
Keloid disease (KD) is a common connective tissue disorder of unknown aetiopathogenesis
with ill-defined treatment. Keloid scars present as exophytic fibroproliferative reticular …