Exploring heterogeneity: A dive into preclinical models of cancer cachexia
F Morena, AR Cabrera… - American Journal of …, 2024 - journals.physiology.org
Cancer cachexia (CC) is a multifactorial and complex syndrome experienced by up to 80%
of patients with cancer and implicated in∼ 40% of cancer-related deaths. Given its …
of patients with cancer and implicated in∼ 40% of cancer-related deaths. Given its …
Systemic metabolic crosstalk as driver of cancer cachexia
E Wyart, G Carrà, E Angelino, F Penna… - Trends in Endocrinology …, 2025 - cell.com
Cachexia is a complex metabolic disorder characterized by negative energy balance due to
increased consumption and lowered intake, leading to progressive tissue wasting and …
increased consumption and lowered intake, leading to progressive tissue wasting and …
Tryptophan metabolism and kynurenine metabolites in cancer: systemic nutritional and metabolic implications
Trp metabolism has implications in immune and energy balance in cancer. The modulation
of Trp and kynurenines have impact on central nervous system mechanisms, including …
of Trp and kynurenines have impact on central nervous system mechanisms, including …
Metformin alleviates colitis-associated colorectal cancer via inhibition of the TLR4/MyD88/NFκB/MAPK pathway and macrophage M2 polarization
X Lai, B Liu, Y Wan, P Zhou, W Li, W Hu… - International …, 2025 - Elsevier
Background Colon inflammation plays an essential role in the development and progression
of colorectal cancer. Emerging evidence from clinical and animal studies indicates that …
of colorectal cancer. Emerging evidence from clinical and animal studies indicates that …
Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia
R Pradhan, W Dieterich, A Natarajan, R Schwappacher… - Cancers, 2024 - mdpi.com
Simple Summary Cancer cachexia (CC) is a syndrome affecting advanced cancer patients,
causing inflammation, metabolic dysfunction, and a decline in quality of life. It increases the …
causing inflammation, metabolic dysfunction, and a decline in quality of life. It increases the …
Serum metabolomics analysis of malnutrition in patients with gastric cancer: a cross sectional study
Background Although malnutrition is common in cancer patients, its molecular mechanisms
has not been fully clarified. This study aims to identify significantly differential metabolites …
has not been fully clarified. This study aims to identify significantly differential metabolites …