Placental origins of chronic disease
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …
events during their intrauterine phase of development. Biologically this should not be …
Muscle as a “mediator” of systemic metabolism
Skeletal and cardiac muscles play key roles in the regulation of systemic energy
homeostasis and display remarkable plasticity in their metabolic responses to caloric …
homeostasis and display remarkable plasticity in their metabolic responses to caloric …
PLA2G6 guards placental trophoblasts against ferroptotic injury
O Beharier, VA Tyurin, JP Goff… - Proceedings of the …, 2020 - National Acad Sciences
The recently identified ferroptotic cell death is characterized by excessive accumulation of
hydroperoxy-arachidonoyl (C20: 4)-or adrenoyl (C22: 4)-phosphatidylethanolamine (Hp …
hydroperoxy-arachidonoyl (C20: 4)-or adrenoyl (C22: 4)-phosphatidylethanolamine (Hp …
Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia
L Ji, J Brkić, M Liu, G Fu, C Peng, YL Wang - Molecular aspects of medicine, 2013 - Elsevier
The placenta is a transient organ that forms during pregnancy to support the growth and
development of the fetus. During human placental development, trophoblast cells …
development of the fetus. During human placental development, trophoblast cells …
The Mediator complex and transcription regulation
ZC Poss, CC Ebmeier, DJ Taatjes - Critical reviews in biochemistry …, 2013 - Taylor & Francis
The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …
Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …
MicroRNAs in human placental development and pregnancy complications
MicroRNAs (miRNAs) are small non-coding RNAs, which function as critical
posttranscriptional regulators of gene expression by promoting mRNA degradation and …
posttranscriptional regulators of gene expression by promoting mRNA degradation and …
The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes
RB Donker, JF Mouillet, T Chu, CA Hubel… - Molecular human …, 2012 - academic.oup.com
The largest gene cluster of human microRNAs (miRNAs), the chromosome 19 miRNA
cluster (C19MC), is exclusively expressed in the placenta and in undifferentiated cells. The …
cluster (C19MC), is exclusively expressed in the placenta and in undifferentiated cells. The …
Hypoxia: a master regulator of microRNA biogenesis and activity
S Nallamshetty, SY Chan, J Loscalzo - Free Radical Biology and Medicine, 2013 - Elsevier
Hypoxia, or low oxygen tension, is a unique environmental stress that induces global
changes in a complex regulatory network of transcription factors and signaling proteins to …
changes in a complex regulatory network of transcription factors and signaling proteins to …
MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach
VN Parikh, RC Jin, S Rabello, N Gulbahce, K White… - Circulation, 2012 - Am Heart Assoc
Background—Pulmonary hypertension (PH) is driven by diverse pathogenic etiologies.
Owing to their pleiotropic actions, microRNA molecules are potential candidates for …
Owing to their pleiotropic actions, microRNA molecules are potential candidates for …