The role of bacterial transport systems in the removal of host antimicrobial peptides in Gram-negative bacteria
Antibiotic resistance is a global issue that threatens our progress in healthcare and life
expectancy. In recent years, antimicrobial peptides (AMPs) have been considered as …
expectancy. In recent years, antimicrobial peptides (AMPs) have been considered as …
Advances in studying protein disorder with solid-state NMR
AB Siemer - Solid state nuclear magnetic resonance, 2020 - Elsevier
Solution NMR is a key tool to study intrinsically disordered proteins (IDPs), whose
importance for biological function is widely accepted. However, disordered proteins are not …
importance for biological function is widely accepted. However, disordered proteins are not …
Ultrashort peptide bioinks support automated printing of large-scale constructs assuring long-term survival of printed tissue constructs
We report about rationally designed ultrashort peptide bioinks, overcoming severe
limitations in current bioprinting procedures. Bioprinting is increasingly relevant in tissue …
limitations in current bioprinting procedures. Bioprinting is increasingly relevant in tissue …
Interaction and dynamics of chemokine receptor CXCR4 binding with CXCL12 and hBD-3
J Penfield, L Zhang - Communications Chemistry, 2024 - nature.com
Chemokine receptor CXCR4 is involved in diverse diseases. A comparative study was
conducted on CXCR4 embedded in a POPC lipid bilayer binding with CXCL12 in full and …
conducted on CXCR4 embedded in a POPC lipid bilayer binding with CXCL12 in full and …
In-cell solid-state NMR studies of antimicrobial peptides
Antimicrobial peptides (AMPs) have attracted attention as alternatives to classic antibiotics
due to their expected limited pressure on bacterial resistance mechanisms. Yet, their modes …
due to their expected limited pressure on bacterial resistance mechanisms. Yet, their modes …
Interaction of Human β Defensin Type 3 (hBD-3) with Different PIP2-Containing Membranes, a Molecular Dynamics Simulation Study
L Zhang - Journal of Chemical Information and Modeling, 2021 - ACS Publications
Human β defensin type 3 (hBD-3) is a cysteine-rich small antibacterial peptide. It belongs to
the human innate immune system. hBD-3 has six cysteine residues, which form three pairs …
the human innate immune system. hBD-3 has six cysteine residues, which form three pairs …
[HTML][HTML] Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria
C Nehls, A Böhling, R Podschun, S Schubert… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Antimicrobial peptides (AMPs) play an important role in the host defense against various
microbes. One of the most efficient human AMPs is the human beta defensin-3 (hBD-3) …
microbes. One of the most efficient human AMPs is the human beta defensin-3 (hBD-3) …
Deuterium solid state NMR studies of intact bacteria treated with antimicrobial peptides
V Booth - Frontiers in Medical Technology, 2021 - frontiersin.org
Solid state NMR has been tremendously useful in characterizing the structure and dynamics
of model membranes composed of simple lipid mixtures. Model lipid studies employing solid …
of model membranes composed of simple lipid mixtures. Model lipid studies employing solid …
Molecular dynamics simulations of human α-defensin 5 (HD5) crossing gram-negative bacterial membrane
Human α-defensin 5 (HD5) is a cationic antimicrobial peptide exhibiting a wide range of
antimicrobial activities. It plays an important role in mucosal immunity of the small intestine …
antimicrobial activities. It plays an important role in mucosal immunity of the small intestine …
How ATP suppresses the fibrillation of amyloid peptides: analysis of the free-energy contributions
Recent experiments have revealed that adenosine triphosphate (ATP) suppresses the
fibrillation of amyloid peptides–a process closely linked to neurodegenerative diseases such …
fibrillation of amyloid peptides–a process closely linked to neurodegenerative diseases such …