Immunological properties of oxygen-transport proteins: hemoglobin, hemocyanin and hemerythrin

CJ Coates, H Decker - Cellular and Molecular Life Sciences, 2017 - Springer
It is now well documented that peptides with enhanced or alternative functionality (termed
cryptides) can be liberated from larger, and sometimes inactive, proteins. A primary example …

Early ovariectomy reveals the germline encoding of natural anti‐A‐ and Tn‐cross‐reactive immunoglobulin M (IgM) arising from developmental O‐GalNAc …

P Arend - Cancer Medicine, 2017 - Wiley Online Library
While native blood group A‐like glycans have not been demonstrated in prokaryotic
microorganisms as a source of human “natural” anti‐A isoagglutinin production, and …

Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish …

A Leduc, C Zatylny-Gaudin, M Robert, E Corre… - BMC genomics, 2018 - Springer
Background Aquaculture production is expected to double by 2030, and demands for
aquafeeds and raw materials are expected to increase accordingly. Sustainable growth of …

Tumour cell lysate-loaded dendritic cell vaccine induces biochemical and memory immune response in castration-resistant prostate cancer patients

D Reyes, L Salazar, E Espinoza, C Pereda… - British journal of …, 2013 - nature.com
Background: Recently, we produced a tumour antigen-presenting cells (TAPCells) vaccine
using a melanoma cell lysate, called TRIMEL, as an antigen source and an activation factor …

[图书][B] Biology and ecology of edible marine bivalve molluscs

R Santhanam - 2018 - taylorfrancis.com
This comprehensive volume provides a plethora of first-hand information on the diversity,
biology, and ecology of edible marine bivalve molluscs. It covers the biology of edible …

A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti-Tumor Activity in Melanoma

S Arancibia, C Espinoza, F Salazar, M Del Campo… - PloS one, 2014 - journals.plos.org
Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as
immunomodulatory proteins with proven anti-cancer properties. The biodiversity of …

[HTML][HTML] Hemocyanins stimulate innate immunity by inducing different temporal patterns of proinflammatory cytokine expression in macrophages

TY Zhong, S Arancibia, R Born, R Tampe… - The Journal of …, 2016 - journals.aai.org
Hemocyanins induce a potent Th1-dominant immune response with beneficial clinical
outcomes when used as a carrier/adjuvant in vaccines and nonspecific immunostimulant in …

[HTML][HTML] A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells inhibiting tumor growth

MA Gleisner, C Pereda, A Tittarelli… - … for ImmunoTherapy of …, 2020 - ncbi.nlm.nih.gov
Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some
patients with cancer. Nevertheless, many individuals remain refractory or acquire resistance …

Immunotherapeutic potential of mollusk hemocyanins in combination with human vaccine adjuvants in murine models of oral cancer

JJ Mora Román, M Del Campo, J Villar… - Journal of …, 2019 - Wiley Online Library
Mollusk hemocyanins have been used for decades in immunological and clinical
applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the …

Antitumor Activity of Bioactive Compounds from Rapana venosa against Human Breast Cell Lines

M Petrova, Z Vlahova, M Schröder, J Todorova… - Pharmaceuticals, 2023 - mdpi.com
This study is the first report describing the promising antitumor activity of biologically active
compounds isolated from the hemolymph of marine snail Rapana venosa—a fraction with …