Neutralizing antibodies (nAbs) are being increasingly used as passive antiviral reagents in
prophylactic and therapeutic modalities and to guide viral vaccine design. In vivo, nAbs can …

Since their first recognition in human cases about four decades ago, rotaviruses have
remained the leading cause of acute severe dehydrating diarrhea among infants and young …

Antibodies that can bind to viruses but are unable to block infection in cell culture are known
as “nonneutralizing antibodies.” Such antibodies are nearly universally elicited following …

Trim-Away is a recently developed technology that exploits off-the-shelf antibodies and the
RING E3 ligase and cytosolic antibody receptor TRIM21 to carry out rapid protein depletion …

Human norovirus (HuNoV) is the leading cause of acute gastroenteritis (AGE) worldwide,
which is highly stable and contagious, with a few virus particles being sufficient to establish …

Rotaviruses (RVs) are endemic in swine populations, and all swine herds certainly have a
history of RV infection and circulation. Rotavirus A (RVA) and C (RVC) are the most common …

Rotaviruses are major causes of acute gastroenteritis in infants and young children
worldwide and also cause disease in the young of many other mammalian and of avian …

Tripartite motif-containing protein 21 (TRIM21), an E3 ubiquitin ligase, plays a critical role in
the host antiviral response. However, the mechanism and antiviral spectrum of TRIM21 in …

Species A rotavirus (RVA) vaccines based on live attenuated viruses are used worldwide in
humans. The recent establishment of a reverse genetics system for rotoviruses (RVs) has …

Introduction Rotavirus is the primary cause of severe acute gastroenteritis among children
under the age of five globally, leading to 128,500 to 215,000 vaccine-preventable deaths …