Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

The dynamic turnover of actin filaments (F-actin) controls cellular motility in eukaryotes and
is coupled to changes in the F-actin nucleotide state,–. It remains unclear how F-actin …

Cell migration is an essential process, both in unicellular organisms such as amoeba and as
individual or collective motility in highly developed multicellular organisms like mammals. It …

ATP-hydrolysis-coupled actin polymerization is a fundamental mechanism of cellular force
generation,–. In turn, force, and actin filament (F-actin) nucleotide state regulate actin …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Recently, a consensus has emerged that cofilin severing activity can generate free actin
filament ends that are accessible for F-actin polymerization and depolymerization without …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

The function of actin is coupled to the nucleotide bound to its active site. ATP hydrolysis is
activated during polymerization; a delay between hydrolysis and inorganic phosphate (Pi) …