Integrating immunotherapy into multimodal treatment of head and neck cancer
Simple Summary Immune checkpoint inhibitors have become the standard of care therapy in
a multimodal setting for recurrent/metastatic HNSCC. Multiple clinical trials have recently …
a multimodal setting for recurrent/metastatic HNSCC. Multiple clinical trials have recently …
Point/counterpoint: do we de-escalate treatment of HPV-associated oropharynx cancer now? And how?
LJ Wirth, B Burtness, CAO Nathan… - American Society of …, 2019 - ascopubs.org
HPV-positive (HPV+) oropharyngeal carcinoma (OPC) continues to increase in incidence
across the globe. Multimodality treatment offers a high likelihood of cure in HPV+ OPC but …
across the globe. Multimodality treatment offers a high likelihood of cure in HPV+ OPC but …
Severe oral mucositis after intensity-modulated radiation therapy for head and neck cancer
Importance Oral mucositis (OM) is a common and debilitating adverse effect observed in
patients with head and neck cancer (HNC) receiving radiation therapy (RT). Previous …
patients with head and neck cancer (HNC) receiving radiation therapy (RT). Previous …
Eliminating postoperative radiation to the pathologically node-negative neck: long-term results of a prospective phase II study
JA Contreras, C Spencer, T DeWees… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE The volume treated with postoperative radiation therapy (PORT) is a mediator of
toxicity, and reduced volumes result in improved quality of life (QOL). In this phase II trial …
toxicity, and reduced volumes result in improved quality of life (QOL). In this phase II trial …
Association of posttreatment lymphopenia and elevated neutrophil-to-lymphocyte ratio with poor clinical outcomes in patients with human papillomavirus–negative …
Importance Better biomarkers are needed for human papillomavirus (HPV)–negative
oropharyngeal cancer (OPC) to identify patients at risk of recurrence. Lymphopenia and an …
oropharyngeal cancer (OPC) to identify patients at risk of recurrence. Lymphopenia and an …
Novel Strategies to Effectively De-escalate Curative-Intent Therapy for Patients With HPV-Associated Oropharyngeal Cancer: Current and Future Directions.
KAR Price, AC Nichols, CJ Shen… - American Society of …, 2020 - europepmc.org
The treatment of patients with HPV-associated oropharyngeal cancer (HPV-OPC) is rapidly
evolving and challenging the standard of care of definitive radiotherapy with concurrent …
evolving and challenging the standard of care of definitive radiotherapy with concurrent …
Ipsilateral radiation for squamous cell carcinoma of the tonsil: American Radium Society appropriate use criteria executive summary
CJ Tsai, TJ Galloway, DN Margalit, RL Bakst… - Head & …, 2021 - Wiley Online Library
Background We conducted the current systemic review to provide up‐to‐date literature
summary and optimal evidence‐based recommendations for ipsilateral radiation for …
summary and optimal evidence‐based recommendations for ipsilateral radiation for …
Risk and rate of occult contralateral nodal disease in surgically treated patients with human papillomavirus− related squamous cell carcinoma of the base of the …
AS Last, P Pipkorn, S Chen, D Kallogjeri… - … –Head & Neck …, 2020 - jamanetwork.com
Importance The optimal treatment strategy for patients with human papillomavirus (HPV)−
related oropharyngeal squamous cell carcinoma (OPSCC) of the base of the tongue (BOT) …
related oropharyngeal squamous cell carcinoma (OPSCC) of the base of the tongue (BOT) …
Volume de-escalation in radiation therapy: state of the art and new perspectives
Purpose New RT techniques and data emerging from follow-up for several tumor sites
suggest that treatment volume de-escalation may permit to minimize therapy-related side …
suggest that treatment volume de-escalation may permit to minimize therapy-related side …
Patient-reported quality of life and symptom burden measures in human papillomavirus associated oropharyngeal cancer–A review of the literature and PRO …
The emergence of human papillomavirus-associated oropharyngeal cancer (HPVOPC) has
resulted in an explosion of clinical research offering reduced toxicity and improved health …
resulted in an explosion of clinical research offering reduced toxicity and improved health …