Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

The activity-dependent structural and functional plasticity of dendritic spines has led to the
long-standing belief that these neuronal compartments are the subcellular sites of learning …

Rett syndrome is a rare, genetic neurodevelopmental disorder. Trofinetide is a synthetic
analog of glycine–proline–glutamate, the N-terminal tripeptide of the insulin-like growth …

Oxidative stress and mitochondrial dysfunction contribute greatly to fluoride-induced
cognitive impairment and behavioural disorders. Honokiol, a natural biphenolic compound …

A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of
toxicological hazard information for most compounds. Therefore, new approaches are being …

The structure and dynamics of dendritic spines reflect the strength of synapses, which are
severely affected in different brain diseases. Therefore, understanding the ultra-structure …

Background Temporal lobe epilepsy (TLE) remains one of the most drug-resistant focal
epilepsies. Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic …

Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …

Abstract Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation,
maturation and plasticity of Central Nervous System (CNS) synapses. Acute exposure of …

Background Trofinetide was approved for the treatment of Rett syndrome based on the
results of the phase 3, randomized, placebo-controlled, 12-week LAVENDER study. Rett …