Opioids for chronic pain management in patients with dialysis-dependent kidney failure

DG Tobin, MB Lockwood, PL Kimmel… - Nature Reviews …, 2022 - nature.com
Chronic pain is highly prevalent among adults treated with maintenance haemodialysis (HD)
and has profound negative effects. Over four decades, research has demonstrated that 50 …

The role of pharmacogenomics in opioid prescribing

AK Wong, AA Somogyi, J Rubio, J Philip - Current Treatment Options in …, 2022 - Springer
Opinion statement Pharmacogenomics is increasingly important to guide objective, safe,
and effective individualised prescribing. Personalised prescribing has revolutionised …

Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness

WH Roughan, AI Campos, LM García-Marín… - Frontiers in …, 2021 - frontiersin.org
The bidirectional relationship between depression and chronic pain is well-recognized, but
their clinical management remains challenging. Here we characterize the shared risk factors …

[HTML][HTML] Distributed sensor and actuator networks for closed-loop bioelectronic medicine

G Bhave, JC Chen, A Singer, A Sharma, JT Robinson - Materials Today, 2021 - Elsevier
Designing implantable bioelectronic systems that continuously monitor physiological
functions and simultaneously provide personalized therapeutic solutions for patients …

CYP2D6 phenotypes and opioid metabolism: the path to personalized analgesia

P Ballester, J Muriel, AM Peiró - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Opioids play a fundamental role in chronic pain, especially considering when 1
of 5 Europeans adults, even more in older females, suffer from it. However, half of them do …

Pharmacogenomics of pain management: the impact of specific biological polymorphisms on drugs and metabolism

EM Cornett, MA Carroll Turpin, A Pinner… - Current oncology …, 2020 - Springer
Abstract Purpose of Review Pain is multifactorial and complex, often with a genetic
component. Pharmacogenomics is a relative new field, which allows for the development of …

Codeine and tramadol use in athletes: a potential for abuse

T Zandonai, M Escorial, AM Peiró - Frontiers in pharmacology, 2021 - frontiersin.org
Analgesic use by athletes is common (Overbye, 2020). It has been observed that athletes
used analgesics up to four times more often than their age-matched general population …

Impact of a sensory stimulation program conducted by family members on the consciousness and pain levels of ICU patients: A mixed method study

M Adineh, N Elahi, S Molavynejad, S Jahani… - Frontiers in …, 2022 - frontiersin.org
Background The results of several studies show the different effects of a balanced sensory
stimulation program (SSP) on patients with brain injury admitted to the intensive care unit …

Molecular basis of cancer pain management: an updated review

A V. Subramaniam, AH Salem Yehya, CE Oon - Medicina, 2019 - mdpi.com
Pain can have a significantly negative impact on the quality of life of patients. Therefore,
patients may resort to analgesics to relieve the pain. The struggle to manage pain in cancer …

Evaluation of phenotypic and genotypic variations of drug metabolising enzymes and transporters in chronic pain patients facing adverse drug reactions or non …

V Rollason, C Lloret-Linares, KI Lorenzini… - Journal of personalized …, 2020 - mdpi.com
This retrospective study evaluates the link between an adverse drug reaction (ADR) or a non-
response to treatment and cytochromes P450 (CYP), P-glycoprotein (P-gp) or catechol-O …