Over the past century, treatment of malignant tumors of the brain has remained a challenge.
Refinements in neurosurgical techniques, discovery of powerful chemotherapeutic agents …

To protect tissues and the organism from disease, potentially harmful cells are removed
through programmed cell death processes, including apoptosis and necroptosis. These …

Recent studies have shown that meningeal lymphatic vessels (MLVs), which are located
both dorsally and basally beneath the skull, provide a route for draining macromolecules …

The hypoxia-inducible factor 2α (HIF-2α) is a key oncogenic driver in clear cell renal cell
carcinoma (ccRCC). Our first HIF-2α inhibitor PT2385 demonstrated promising proof of …

Glioblastoma (GBM) is the most common brain tumor in adults and the mesenchymal GBM
subtype was reported to be the most malignant, presenting severe hypoxia and necrosis …

Protein-coding genes account for only~ 2% of the human genome, whereas the vast majority
of transcripts are non-coding RNAs (ncRNAs) including long ncRNAs (lncRNAs). A growing …

Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate
has not markedly improved, despite new radical surgery protocols, the introduction of new …

With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome
therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at …

Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain,
remaining incurable with a median survival time of only 15 months. In an effort to identify …

Human cancers are characterized by a number of hallmarks, including sustained
proliferative signaling, evasion of growth suppressors, activated invasion and metastasis …