Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Over the past decade, zebrafish are being increasingly used in assessing the effects of
chemical compounds. Especially, the embryos and larvae, due to their microscopically small …

Abstract Myotonic Dystrophy type 1 (DM1) is a dominant neuromuscular disease caused by
nuclear-retained RNAs containing expanded CUG repeats. These toxic RNAs alter the …

Abstract Background The Deepwater Horizon disaster was the largest marine oil spill in
history, and total vertical exposure of oil to the water column suggests it could impact an …

Satellite cells, also known as muscle stem cells, are responsible for skeletal muscle growth
and repair in mammals. Pax7 and Pax3 transcription factors are established satellite cell …

Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are
neuromuscular disorders that primarily affect boys due to an X-linked mutation in the DMD …

In a forward genetic approach to identify novel genes for congenital muscle diseases, a
zebrafish mutant, designated patchytail, was identified that exhibits degenerating muscle …

We report a multifunctional gene-trapping approach, which generates full-length Citrine
fusions with endogenous proteins and conditional mutants from a single integration event of …

Muscular dystrophies are a group of genetic disorders that specifically affect skeletal muscle
and are characterized by progressive muscle degeneration and weakening. To develop …

Duchenne muscular dystrophy (DMD) represents one of the most devastating types of
muscular dystrophies which affect boys already at early childhood. Despite the fact that the …