Remodeling of large and small arteries contributes to the development and complications of
hypertension. The focus of this review is some of the mechanisms involved in the …

In the past 2 decades, it has been appreciated that the functions of the extracellular matrix
(ECM) are not entirely structural. ECM components interact with specific adhesion receptors …

We tested the hypothesis that angiotensin II-induced hypertension is associated with an
increase in vascular. O2-production, and characterized the oxidase involved in this process …

Oxygen-derived free radicals are involved in the vascular response to angiotensin II (Ang II),
but the role of NADPH oxidase, its subunit proteins, and their vascular localization remain …

The renin-angiotensin system regulates normal cardiovascular homeostasis and is activated
in certain forms of hypertension and in heart failure. Angiotensin II has multiple physiological …

Objectives Angiotensin (Ang) II stimulates vascular reactive oxygen species generation via
NAD (P) H oxidase activation. We investigated whether vascular NAD (P) H oxidase …

Recent studies have pointed out the implication of angiotensin II (Ang II) in various
pathological settings. However, the molecular mechanisms and the AngII receptor (AT) …

Cardiovascular disease (CVD) rates in adulthood are high in premature infants;
unfortunately, the underlying mechanisms are not well defined. In this review, we discuss …

Recent experimental data suggest marked similarities between the effects of hypertension
and hypercholesterolemia on the arterial intima. Both conditions also seem to exert …

Cerebral small vessel disease (CSVD) causes dementia and gait disturbance due to
arteriopathy. Cerebral autosomal recessive arteriopathy with subcortical infarcts and …