Objectives To determine whether BCG vaccination protects against Mycobacterium
tuberculosis infection as assessed by interferon γ release assays (IGRA) in children. Design …

The individual-and population-level impact of household tuberculosis exposure on
transmission is unclear but may have implications for the effectiveness and implementation …

Executive summary Tuberculosis (TB) strains with drug resistance (DR-TB) are more difficult
to treat than drug-susceptible ones, and threaten global progress towards the targets set by …

1.1 Background Latent tuberculosis infection (LTBI) is defined as a state of persistent
immune response to stimulation by Mycobacterium tuberculosis antigens with no evidence …

Background: Interferon-gamma release assays (IGRA) are well-established
immunodiagnostic tests for tuberculosis (TB) in adults. In children these tests are associated …

Background Lack of a gold standard for latent TB infection has precluded direct
measurement of test characteristics of the tuberculin skin test and interferon-γ release …

Young children living with a tuberculosis patient are at high risk of Mycobacterium
tuberculosis infection and disease. WHO guidelines promote active screening and isoniazid …

Background It is recommended that young child contacts of sputum smear positive
tuberculosis cases receive isoniazid preventive therapy (IPT) but reported adherence is low …

Background Screening and treatment of latent TB infection (LTBI) and TB disease could
reduce diabetes mellitus (DM)-associated TB. We aimed to describe the prevalence of LTBI …

BACKGROUND Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB)[(Zopf
1883) Lehmann and Neumann 1896], is a major cause of morbidity and mortality. Nearly …