Giardia—from genome to proteome

RCA Thompson, P Monis - Advances in parasitology, 2012 - Elsevier
In this review, the current status of genomic and proteomic research on Giardia is examined
in terms of evolutionary biology, phylogenetic relationships and taxonomy. The review also …

Microtubule organelles in Giardia

KD Hagen, SG McInally, ND Hilton, SC Dawson - Advances in parasitology, 2020 - Elsevier
Giardia lamblia is a widespread parasitic protist with a complex MT cytoskeleton that is
critical for motility, attachment, mitosis and cell division, and transitions between its two life …

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

G Manning, DS Reiner, T Lauwaet, M Dacre, A Smith… - Genome biology, 2011 - Springer
Background The major human intestinal pathogen Giardia lamblia is a very early branching
eukaryote with a minimal genome of broad evolutionary and biological interest. Results To …

Induction of virulence factors in Giardia duodenalis independent of host attachment

SJ Emery, M Mirzaei, D Vuong, D Pascovici… - Scientific reports, 2016 - nature.com
Giardia duodenalis is responsible for the majority of parasitic gastroenteritis in humans
worldwide. Host-parasite interaction models in vitro provide insights into disease and …

Novel Structural Components of the Ventral Disc and Lateral Crest in Giardia intestinalis

KD Hagen, MP Hirakawa, SA House… - PLoS neglected …, 2011 - journals.plos.org
Giardia intestinalis is a ubiquitous parasitic protist that is the causative agent of giardiasis,
one of the most common protozoan diarrheal diseases in the world. Giardia trophozoites …

[HTML][HTML] Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics

B Balan, SJ Emery-Corbin, JJ Sandow… - International Journal for …, 2021 - Elsevier
Cyst formation in the parasitic protist Giardia duodenalis is critical to its transmission.
Existing proteomic data quantifies only 17% of coding genes transcribed during encystation …

CilioGenics: an integrated method and database for predicting novel ciliary genes

MS Pir, E Begar, F Yenisert, HC Demirci… - Nucleic Acids …, 2024 - academic.oup.com
Uncovering the full list of human ciliary genes holds enormous promise for the diagnosis of
cilia-related human diseases, collectively known as ciliopathies. Currently, genetic …

[HTML][HTML] An update on cell division of Giardia duodenalis trophozoites

FA Lagunas-Rangel, J Yee… - Microbiological Research, 2021 - Elsevier
Giardia duodenalis is a flagellated protozoan that is responsible for many cases of diarrheal
disease worldwide and is characterized by its great divergence from the model organisms …

'Disc-o-fever': getting down with Giardia's groovy microtubule organelle

C Nosala, KD Hagen, SC Dawson - Trends in Cell Biology, 2018 - cell.com
Protists have evolved a myriad of highly specialized cytoskeletal organelles that expand
known functional capacities of microtubule (MT) polymers. One such innovation–the ventral …

Remodeling Cildb, a popular database for cilia and links for ciliopathies

O Arnaiz, J Cohen, AM Tassin, F Koll - Cilia, 2014 - Springer
Background New generation technologies in cell and molecular biology generate large
amountsof data hard to exploit for individual proteins. This is particularly true forciliary and …