Trypanosoma cruzi-specific CD8+ T cells and other immunological hallmarks in chronic Chagas cardiomyopathy: Two decades of research

CJ Puerta, A Cuellar, P Lasso, J Mateus… - Frontiers in Cellular …, 2023 - frontiersin.org
Trypanosoma cruzi, the causal agent of Chagas disease, has coexisted with humans for
thousands of years. Therefore, the parasite has developed several mechanisms of antigenic …

Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle

CD Kaufman, C Farré, L Biscari, AR Pérez… - Frontiers in Cell and …, 2023 - frontiersin.org
Considering the extensive and widespread impact on individuals, cancer can presently be
categorized as a pandemic. In many instances, the development of tumors has been linked …

[HTML][HTML] Mammalian cellular culture models of Trypanosoma cruzi infection: a review of the published literature

GA Duran-Rehbein, JC Vargas-Zambrano, A Cuéllar… - Parasite, 2014 - ncbi.nlm.nih.gov
Cellular culture infection with Trypanosoma cruzi is a tool used to dissect the biological
mechanisms behind Chagas disease as well as to screen potential trypanocidal …

Interferon-Gamma Promotes Infection of Astrocytes by Trypanosoma cruzi

RR Silva, RM Mariante, AA Silva, ALB Dos Santos… - PLoS …, 2015 - journals.plos.org
The inflammatory cytokine interferon-gamma (IFNγ) is crucial for immunity against
intracellular pathogens such as the protozoan parasite Trypanosoma cruzi, the causative …

Priming astrocytes with TNF enhances their susceptibility to Trypanosoma cruzi infection and creates a self-sustaining inflammatory milieu

AA Silva, RR Silva, D Gibaldi, RM Mariante… - Journal of …, 2017 - Springer
Background In conditions of immunosuppression, the central nervous sty 5ystem (CNS) is
the main target tissue for the reactivation of infection by Trypanosoma cruzi, the causative …

The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication

AL Pacheco, G Vicentini, KC Matteucci… - Journal of leukocyte …, 2019 - academic.oup.com
Abstract Trypanossoma cruzi (T. cruzi), the causative protozoan of Chagas disease (CD)
invades many cell types, including central nervous system (CNS) cells triggering local …

[HTML][HTML] Trypanosoma cruzi infection induces proliferation and impairs migration of a human breast cancer cell line

ACA Silveira, RC de Oliveira, CC Rodrigues… - Experimental …, 2023 - Elsevier
Breast cancer is considered the type of cancer that most affects women in the world. The
triple negative breast cancer is considered aggressive with poor prognosis. In the 1930s …

Priming Astrocytes With HIV-Induced Reactive Oxygen Species Enhances Their Trypanosoma cruzi Infection

J Urquiza, C Cevallos, MM Elizalde… - Frontiers in …, 2020 - frontiersin.org
Introduction: Trypanosoma cruzi is an intracellular protozoa and etiological agent that
causes Chagas disease. Its presence among the immunocompromised HIV-infected …

Establishment of larval zebrafish as an animal model to investigate Trypanosoma cruzi motility in vivo

V Akle, N Agudelo-Dueñas… - Journal of …, 2017 - pmc.ncbi.nlm.nih.gov
Chagas disease is a parasitic infection caused by Trypanosoma cruzi, whose motility is not
only important for localization, but also for cellular binding and invasion. Current animal …

Experimental Trypanosoma cruzi Infection Induces Pain in Mice Dependent on Early Spinal Cord Glial Cells and NFκB Activation and Cytokine Production

SM Borghi, V Fattori, TT Carvalho… - Frontiers in …, 2021 - frontiersin.org
The neglected tropical infirmity Chagas disease (CD) presents high mortality. Its etiological
agent T. cruzi is transmitted by infected hematophagous insects. Symptoms of the acute …