More than 60 years ago, Eugene Kennedy and coworkers elucidated the endoplasmic
reticulum (ER)-based pathways of glycerolipid synthesis, including the synthesis of …

Thermogenesis is the production of heat that occurs in all warm-blooded animals. During
cold exposure, there is obligatory thermogenesis derived from body metabolism as well as …

Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) is caused by loss-of-function
mutations in SEIPIN, a protein implicated in both adipogenesis and lipid droplet expansion …

Abstract Glycerol-3-phosphate acyltransferase (GPAT) is the rate-limiting enzyme in the de
novo pathway of glycerolipid synthesis. It catalyzes the conversion of glycerol-3-phosphate …

Diet, hormones, gene transcription, and posttranslational modifications control the hepatic
metabolism of FAs; metabolic dysregulation causes chronic diseases, including …

The successive acylation of glycerol-3-phosphate (G3P) by glycerol-3-phosphate
acyltransferases and acylglycerol-3-phosphate acyltransferases produces phosphatidic acid …

Seipin, the gene that causes Berardinelli‐Seip congenital lipodystrophy type 2 (BSCL 2), is
important for adipocyte differentiation and lipid homeostasis. Previous studies in Drosophila …

Preclinical studies established BAT as an important target to combat cardiometabolic
disorders and elucidated underlying mechanisms whereas clinical studies identified …

Brown adipose tissue uptake of glucose and fatty acids is very high during nonshivering
thermogenesis. Adrenergic stimulation markedly increases glucose uptake, de novo …

Catecholamines stimulate the mobilization of stored triglycerides in adipocytes to provide
fatty acids (FAs) for other tissues. However, a large proportion is taken back up and either …