[HTML][HTML] Targeting the orexin/hypocretin system for the treatment of neuropsychiatric and neurodegenerative diseases: From animal to clinical studies

M Ten-Blanco, Á Flores, L Cristino… - Frontiers in …, 2023 - Elsevier
Orexins (also known as hypocretins) are neuropeptides located exclusively in hypothalamic
neurons that have extensive projections throughout the central nervous system and bind two …

Lipid endocannabinoids in energy metabolism, stress and developmental programming

MM Almeida, CP Dias-Rocha, C Calviño… - Molecular and Cellular …, 2022 - Elsevier
The endocannabinoid system (ECS) regulates brain development and function, energy
metabolism and stress in a sex-, age-and tissue-dependent manner. The ECS comprises …

A molecular network map of orexin-orexin receptor signaling system

O Chatterjee, L Gopalakrishnan, D Pullimamidi… - Journal of Cell …, 2023 - Springer
Orexins are excitatory neuropeptides, which are predominantly associated with feeding
behavior, sleep-wake cycle and energy homeostasis. The orexinergic system comprises of …

[HTML][HTML] Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity

AC Fernández-Rilo, N Forte, L Palomba, L Tunisi… - Molecular …, 2023 - Elsevier
Abstract Objective Orexin-A (OX-A) is a neuropeptide produced selectively by neurons of the
lateral hypothalamus. It exerts powerful control over brain function and physiology by …

Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens

I Kalló, A Omrani, FJ Meye, H de Jong… - Brain Structure and …, 2022 - Springer
Orexin neurons are involved in homeostatic regulatory processes, including arousal and
feeding, and provide a major input from the hypothalamus to the ventral tegmental area …

Orexin recruits non‐selective cationic conductance and endocannabinoid to dynamically modulate firing of caudal pontine reticular nuclear neurones

QC Qiao, SY Wen, YB Jiang, H Feng… - The Journal of …, 2023 - Wiley Online Library
The neuropeptide orexin is involved in motor circuit function. However, its modulation on
neuronal activities of motor structures, integrating orexin's diverse downstream molecular …

Maternal high-fat diet decreases milk endocannabinoids with sex-specific changes in the cannabinoid and dopamine signaling and food preference in rat offspring

CP Dias-Rocha, JCB Costa, YS Oliveira… - Frontiers in …, 2023 - frontiersin.org
Introduction Maternal high-fat (HF) diet during gestation and lactation programs obesity in rat
offspring associated with sex-dependent and tissue-specific changes of the …

Hypothalamic cannabinoid signaling: Consequences for eating behavior

MN Lord, EE Noble - Pharmacology Research & Perspectives, 2024 - Wiley Online Library
In parallel to the legalization of cannabis for both medicinal and recreational purposes,
cannabinoid use has steadily increased over the last decade in the United States …

Imaging flow cytometry of tumoroids: A new method for studying GPCR expression

V Gratio, S Dayot, S Benadda, P Nicole… - Cytometry Part …, 2024 - Wiley Online Library
Fluorescence confocal microscopy is commonly used to analyze the regulation membrane
proteins expression such as G protein‐coupled receptors (GPCRs). With this approach, the …

Male mice engaging differently in emotional eating present distinct plasmatic and neurological profiles

C Heberden, E Maximin, S Rabot… - Nutritional …, 2023 - Taylor & Francis
Objective: Stressed individuals tend to turn to calorie-rich food, also known as 'comfort
food'for the temporary relief it provides. The emotional eating drive is highly variable among …