Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a
burden on global health and the economy. The enormously rising environmental changes …

Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

Initiation and development of cancer depend on multiple factors that mutations in genes and
epigenetic level can be considered as important drivers. Epigenetic factors include a large …

As a phenolic acid compound, caffeic acid (CA) can be isolated from different sources such
as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative …

Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

It is generally accepted that diet-derived polyphenols are bioactive compounds with several
potentially beneficial effects on human health. In general, polyphenols have several …

The human gastrointestinal tract harbors a diverse range of microbial species, which helps
to regulate various biological processes such as homeostasis of the gut barrier, stimulation …

Although Warburg's discovery of intensive glucose uptake by tumors, followed by lactate
fermentation in oxygen presence of oxygen was made a century ago, it is still an area of …

Cancer is a severe public health problem. Resveratrol is a famous natural compound that
has various bioactivities, such as antioxidant, anti-inflammatory, antidiabetic and antiaging …

ROS include hydroxyl radicals (HO.), superoxide (O2..), and hydrogen peroxide (H2O2).
ROS are typically produced under physiological conditions and play crucial roles in living …