Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity

K Gupta, G Kaur, T Pathak, I Banerjee - Gene, 2022 - Elsevier
The COVID-19 pandemic has spawned global health crisis of unprecedented magnitude,
claiming millions of lives and pushing healthcare systems in many countries to the brink …

[HTML][HTML] Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review

P Gianni, M Goldin, S Ngu, S Zafeiropoulos… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) causes acute microvascular thrombosis in
both venous and arterial structures which is highly associated with increased mortality. The …

Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups

L Hurler, Á Szilágyi, F Mescia, L Bergamaschi… - Frontiers in …, 2023 - frontiersin.org
Introduction While complement is a contributor to disease severity in severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement …

Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19

MAF Queiroz, AM Santiago, WRS Brito… - Frontiers in …, 2023 - frontiersin.org
Introduction Mannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis
and activation of the complement system in response to different microorganisms, and may …

Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review

M Tziastoudi, C Cholevas, I Stefanidis… - Annals of Clinical …, 2022 - Wiley Online Library
Abstract COVID‐19 and ME/CFS present with some similar symptoms, especially physical
and mental fatigue. In order to understand the basis of these similarities and the possibility of …

[HTML][HTML] Genomic Landscape of Susceptibility to Severe COVID-19 in the Slovenian Population

A Kovanda, T Lukežič, A Maver, H Vokač Križaj… - International Journal of …, 2024 - mdpi.com
Determining the genetic contribution of susceptibility to severe SARS-CoV-2 infection
outcomes is important for public health measures and individualized treatment. Through …

Innate immune gene polymorphisms and COVID-19 prognosis

E Bakaros, I Voulgaridi, V Paliatsa, N Gatselis… - Viruses, 2023 - mdpi.com
COVID-19 is characterized by a heterogeneous clinical presentation and prognosis. Risk
factors contributing to the development of severe disease include old age and the presence …

Soluble IL-2R levels at baseline predict the development of severe respiratory failure and mortality in COVID-19 patients

NK Gatselis, V Lygoura, A Lyberopoulou, G Giannoulis… - Viruses, 2022 - mdpi.com
Risk stratification of coronavirus disease-19 (COVID-19) patients by simple markers is
critical to guide treatment. We studied the predictive value of soluble interleukin-2 receptor …

The soluble lectin families as novel biomarkers for COVID-19 pneumonia

H Takenaka, A Saito, K Kuronuma, K Moniwa… - in vivo, 2023 - iv.iiarjournals.org
Background/Aim: The lung-specific soluble lectins, SP-A and SP-D have been clinically
used to diagnose interstitial lung disease, but their clinical significance in COVID-19 remains …

Association between mannose binding lectin gene polymorphisms and clinical severity of COVID-19 in children

D Yilmaz, M Soyoz, A Sahin, B Cerci-Alkac… - Molecular Biology …, 2023 - Springer
Background Mannose-binding lectin (MBL) is a member of innate immunity and acts with
MASP (MBL-associated serine protease) to activate the lectin pathway of the complement …