Protein traffic is of critical importance for normal cellular physiology. In eukaryotes, spherical
transport vesicles move proteins and lipids from one internal membrane-bound …

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

Autophagy is a cytosolic quality control process that recognizes substrates through receptor‐
mediated mechanisms. Procollagens, the most abundant gene products in Metazoa, are …

Hsp47, a collagen-specific molecular chaperone that localizes in the endoplasmic reticulum
(ER), is indispensable for molecular maturation of collagen. Hsp47, which is encoded by the …

Pathways localizing proteins to their sites of action are essential for eukaryotic cell
organization and function. Although mechanisms of protein targeting to many organelles …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

Skeletal growth relies on both biosynthetic and catabolic processes,. While the role of the
former is clearly established, how the latter contributes to growth-promoting pathways is less …

In addition to providing a macromolecular scaffold, the extracellular matrix (ECM) is a critical
regulator of cell function by virtue of specific physical, biochemical, and mechanical …

Secretion is the cellular process present in every organism that delivers soluble proteins and
cargoes to the extracellular space. In eukaryotes, conventional protein secretion (CPS) is the …

Collagen export from the endoplasmic reticulum (ER) requires TANGO1, COPII coats, and
retrograde fusion of ERGIC membranes. How do these components come together to …