Emerging roles of exosomal miRNAs in diabetes mellitus

X He, G Kuang, Y Wu, C Ou - Clinical and translational …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

Extracellular vesicles and particles impact the systemic landscape of cancer

S Lucotti, CM Kenific, H Zhang, D Lyden - The EMBO journal, 2022 - embopress.org
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications

YX Xu, SD Pu, X Li, ZW Yu, YT Zhang, XW Tong… - Pharmacological …, 2022 - Elsevier
Exosomes are discoid vesicles with a diameter of 40–160 nm. They are mainly derived from
the multivesicular body formed by the invagination of lysosomal particles in the cell, which …

Exosomes: Isolation, characterization, and biomedical applications

GN Alzhrani, ST Alanazi, SY Alsharif… - Cell Biology …, 2021 - Wiley Online Library
Exosomes are nano‐sized bioactive vesicles of 30–150 nm in diameter. They are secreted
by exocytosis of nearly all type of cells in to the extracellular fluid. Thereby, they can be …

Exosomes and their noncoding RNA cargo are emerging as new modulators for diabetes mellitus

W Chang, J Wang - Cells, 2019 - mdpi.com
Diabetes belongs to a group of metabolic disorders characterized by long term high blood
glucose levels due to either inadequate production of insulin (Type 1 diabetes, T1DM) or …

Adipose-derived mesenchymal stem cells therapy as a new treatment option for diabetes mellitus

A Mikłosz, A Chabowski - The Journal of Clinical Endocrinology …, 2023 - academic.oup.com
The worldwide increase in the prevalence of diabetes mellitus has raised the demand for
new therapeutic strategies targeting diabetic symptoms and its chronic complications …

Mesenchymal stem cell exosomes as a new strategy for the treatment of diabetes complications

J Xiong, H Hu, R Guo, H Wang, H Jiang - Frontiers in Endocrinology, 2021 - frontiersin.org
Diabetes mellitus (DM) is a metabolic disease, now prevalent worldwide, which is
characterized by a relative or absolute lack of insulin secretion leading to chronically …

Stem/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials

Y Wang, Z Tang, P Gu - Cell Death & Disease, 2020 - nature.com
Retinal degeneration (RD) is one of the dominant causes of irreversible vision impairment
and blindness worldwide. However, the current effective therapeutics for RD in the …

Extracellular vesicle therapy for retinal diseases

B Mead, S Tomarev - Progress in retinal and eye research, 2020 - Elsevier
Extracellular vesicles (EV), which include exosomes and microvesicles, are secreted from
virtually every cell. EV contain mRNA, miRNA, lipids and proteins and can deliver this …

[HTML][HTML] Small extracellular vesicle-loaded bevacizumab reduces the frequency of intravitreal injection required for diabetic retinopathy

SK Reddy, AR Ballal, S Shailaja, RN Seetharam… - Theranostics, 2023 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) is associated with retinal neovascularization, hard exudates,
inflammation, oxidative stress and cell death, leading to vision loss. Anti-vascular …