The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation

AL Comer, M Carrier, MÈ Tremblay… - Frontiers in cellular …, 2020 - frontiersin.org
Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Cytokine alterations in schizophrenia: an updated review

S Momtazmanesh, A Zare-Shahabadi… - Frontiers in …, 2019 - frontiersin.org
Schizophrenia, a multisystem disorder with an unknown etiology, is associated with several
immune dysfunctions, including abnormal levels of circulating cytokines. In this review, we …

Neuroinflammation in schizophrenia: the role of nuclear factor kappa B

CE Murphy, AK Walker, CS Weickert - Translational psychiatry, 2021 - nature.com
Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …

[HTML][HTML] The HPA axis dysregulation in severe mental illness: Can we shift the blame to gut microbiota?

B Misiak, I Łoniewski, W Marlicz, D Frydecka… - Progress in Neuro …, 2020 - Elsevier
Accumulating evidence indicates that patients with severe mental disorders, including major
depression, bipolar disorder and schizophrenia present with various alterations of the gut …

The relationship between inflammatory biomarkers and cognitive dysfunction in patients with schizophrenia: A systematic review and meta-analysis

SR Patlola, G Donohoe, DP McKernan - Progress in Neuro …, 2023 - Elsevier
Background Schizophrenia is a complex psychiatric disorder that includes positive and
negative symptoms but also debilitating cognitive deficits. Current pharmacological …

Autism spectrum disorder and schizophrenia: An updated conceptual review

A Jutla, J Foss‐Feig… - Autism …, 2022 - Wiley Online Library
Autism spectrum disorder (ASD) and schizophrenia (SCZ) are separate disorders, with
distinct clinical profiles and natural histories. ASD, typically diagnosed in childhood, is …

[HTML][HTML] Role of IL-6 in the regulation of neuronal development, survival and function

KK Kummer, M Zeidler, T Kalpachidou, M Kress - Cytokine, 2021 - Elsevier
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Understanding the role of the gut microbiome in brain development and its association with neurodevelopmental psychiatric disorders

S Dash, YA Syed, MR Khan - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The gut microbiome has a tremendous influence on human physiology, including the
nervous system. During fetal development, the initial colonization of the microbiome …

C-reactive protein is increased in schizophrenia but is not altered by antipsychotics: meta-analysis and implications

BS Fernandes, J Steiner, HG Bernstein, S Dodd… - Molecular …, 2016 - nature.com
The inflammatory hypothesis of schizophrenia (SZ) posits that inflammatory processes and
neural–immune interactions are involved in its pathogenesis, and may underpin some of its …

Cytokines and C-reactive protein alterations with respect to cognitive impairment in schizophrenia and bipolar disorder: a systematic review

B Misiak, B Stańczykiewicz, K Kotowicz… - Schizophrenia …, 2018 - Elsevier
Background The aim of this article was to perform a systematic review of studies
investigating the association between peripheral levels of cytokines and C-reactive protein …