Validation of the γH2AX biomarker for genotoxicity assessment: a review
B Kopp, L Khoury, M Audebert - Archives of toxicology, 2019 - Springer
The H2AX histone protein is rapidly phosphorylated at the serine-139 position (γH2AX) in
response to a broad range of DNA lesions. γH2AX induction is one of the earliest events in …
response to a broad range of DNA lesions. γH2AX induction is one of the earliest events in …
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair
N Rahmanian, M Shokrzadeh, M Eskandani - DNA repair, 2021 - Elsevier
The phosphorylation of histone variant H2AX and formation of γH2AX is a primary response
to the DNA double-strand breaks (DSBs). Detection of γH2AX is a robust and sensitive tool …
to the DNA double-strand breaks (DSBs). Detection of γH2AX is a robust and sensitive tool …
γH2AX as a marker of DNA double strand breaks and genomic instability in human population studies
DNA double strand breaks (DSB) are the gravest form of DNA damage in eukaryotic cells.
Failure to detect DSB and activate appropriate DNA damage responses can cause genomic …
Failure to detect DSB and activate appropriate DNA damage responses can cause genomic …
[HTML][HTML] Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests
D Kirkland, P Kasper, HJ Martus, L Müller… - … /Genetic Toxicology and …, 2016 - Elsevier
In 2008 we published recommendations on chemicals that would be appropriate to evaluate
the sensitivity and specificity of new/modified mammalian cell genotoxicity tests, in particular …
the sensitivity and specificity of new/modified mammalian cell genotoxicity tests, in particular …
Molecular mechanisms by which in vivo exposure to exogenous chemical genotoxic agents can lead to micronucleus formation in lymphocytes in vivo and ex vivo in …
M Fenech, S Knasmueller, C Bolognesi… - … Research/Reviews in …, 2016 - Elsevier
The purpose of this review is to summarise current knowledge on the molecular
mechanisms by which in vivo exposure to exogenous chemical genotoxins in humans …
mechanisms by which in vivo exposure to exogenous chemical genotoxins in humans …
Genotoxicity of aflatoxins and their precursors in human cells
MG Theumer, Y Henneb, L Khoury, SP Snini, S Tadrist… - Toxicology Letters, 2018 - Elsevier
Aflatoxins are found as food contaminant and some of them demonstrate a carcinogenic
effect. The aflatoxins biosynthetic pathway involves 15 successive steps. The aim of this …
effect. The aflatoxins biosynthetic pathway involves 15 successive steps. The aim of this …
In vitro biocompatibility of mesoporous metal (III; Fe, Al, Cr) trimesate MOF nanocarriers
R Grall, T Hidalgo, J Delic, A Garcia-Marquez… - Journal of Materials …, 2015 - pubs.rsc.org
The high porosity and versatile composition of the benchmarked mesoporous metal (Fe, Al,
Cr) trimesate metal–organic frameworks (MIL-100 (Fe, Al, Cr)) make them very promising …
Cr) trimesate metal–organic frameworks (MIL-100 (Fe, Al, Cr)) make them very promising …
[HTML][HTML] Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms
M Ouedraogo, T Baudoux, C Stévigny, J Nortier… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The increasing use of traditional herbal
medicines around the world requires more scientific evidence for their putative …
medicines around the world requires more scientific evidence for their putative …
The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response
T Nikolova, M Dvorak, F Jung, I Adam… - Toxicological …, 2014 - academic.oup.com
DNA double-strand breaks (DSBs) and blocked replication forks resulting from bulky
adducts and inhibitors of replication activate the DNA damage response (DDR), a signaling …
adducts and inhibitors of replication activate the DNA damage response (DDR), a signaling …