Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation
Y Wan, G Fang, H Chen, X Deng, Z Tang - European Journal of Medicinal …, 2021 - Elsevier
Currently, the arise of drug resistance and undesirable off-target effects of anti-cancer
agents are major challenges for cancer treatment, which energizes medicinal chemists to …
agents are major challenges for cancer treatment, which energizes medicinal chemists to …
A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors
Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …
anticancer drug targets and their selective inhibition is highly desired for the proper …
Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties
In the current medical era, the utilization of a single small molecule to simultaneously target
two distinct molecular targets is emerging as a highly effective strategy in the battle against …
two distinct molecular targets is emerging as a highly effective strategy in the battle against …
A mini review on isatin, an anticancer scaffold with potential activities against neglected tropical diseases (NTDs)
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …
therapeutic fragments in drug design and development. The template has turned out to be …
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
Recent advances in isatin hybrids as potential anticancer agents
Z Ding, M Zhou, C Zeng - Archiv der Pharmazie, 2020 - Wiley Online Library
The isatin framework is a useful template for the development of novel anticancer agents.
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and …
Herein we describe the design and synthesis of two series of sulfonamides featuring N-
unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted …
Herein we report the design and synthesis of novel N-substituted isatins-SLC-0111 hybrids
(6a-f and 9a-l). A structural extension approach was adopted via N-alkylation and N …
(6a-f and 9a-l). A structural extension approach was adopted via N-alkylation and N …
Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies
Carbonic anhydrases isoforms CA IX, and XII are known to be highly expressed in various
human tissues and malignancies. CA IX is a prominent target for especially colorectal …
human tissues and malignancies. CA IX is a prominent target for especially colorectal …
Synthesis and in vitro anticancer activity of certain novel 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas as apoptosis-inducing agents
In connection with our research program on the development of novel anticancer
candidates, herein we report the design and synthesis of novel series of 1-(2-methyl-6 …
candidates, herein we report the design and synthesis of novel series of 1-(2-methyl-6 …