Copper homeostasis is strictly regulated by protein transporters and chaperones, to allow its
correct distribution and avoid uncontrolled redox reactions. Several studies address copper …

Due to its built-up chemoresistance after prolonged usage, the demand for replacing
platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for …

Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …

Osteosarcoma cancers are becoming more common in children and young adults, and
existing treatments have low efficacy and a very high mortality rate, making it pressing to …

The numerous side effects of platinum based chemotherapy has led to the design of new
therapeutics with platinum replaced by another transition metal. Here, we investigated the …

ATP-binding cassette subfamily G and tubulin pharmacological mechanisms decrease the
effectiveness of anticancer drugs by modulating drug absorption and by creating tubulin …

Osteosarcoma (OS) is a frequent bone cancer, affecting largely children and young adults.
Cisplatin (CDDP) has been efficacious in the treatment of different cancer such us OS but …

Metallocompounds are a class of anticancer compounds largely used in the treatment of
several types of solid tumors, including bone cancer. Osteosarcoma (OS) is a primary …

The development of new anticancer compounds is one of the challenges of bioinorganic
and medicinal chemistry. Naringenin and its metal complexes have been recognized as …

Background: Intracellular copper homeostasis requires a complex system. It has shown
considerable prospects for intervening in the tumor microenvironment (TME) by regulating …